Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V5SQ
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| Former ID |
DIB020975
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| Drug Name |
spiramide
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| Synonyms |
AMI-193; R-5808
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C22H26FN3O2
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| Canonical SMILES |
C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCOC4=CC=C(C=C4)F
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| InChI |
1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27)
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| InChIKey |
FJUKDAZEABGEIH-UHFFFAOYSA-N
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| CAS Number |
CAS 510-74-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6524684, 8191916, 11113547, 14804795, 26751754, 26751755, 43124793, 47288884, 47808500, 47808501, 47883138, 56311623, 57316755, 77160247, 85229950, 85788762, 91746247, 103283755, 103821221, 103975696, 104341470, 117511070, 124886921, 124886922, 124886923, 127857576, 135025008, 135610762, 135649934, 135698131, 136352574, 137147741, 142256309, 144204465, 162223889, 163132611, 170466454, 179236208, 198970375, 228249517, 241181723, 241377377, 249934490
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| ChEBI ID |
CHEBI:64207
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Antagonist | [2] |
| 5-HT 2B receptor (HTR2B) | Target Info | Antagonist | [2] | |
| 5-HT 2C receptor (HTR2C) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Serotonin Receptor 2 and STAT3 Signaling | ||||
| SIDS Susceptibility Pathways | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 175). | |||
| REF 2 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. | |||
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