Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V9WU
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| Drug Name |
US9409892, 19
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| Synonyms |
SCHEMBL15268580; CHEMBL3889830; JSYWJICQZNCWHF-UHFFFAOYSA-N; BDBM240924; US9409892, 19; 1-{[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-methyl}-cyclopentanecarboxylic acid
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C24H21N3O5
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| Canonical SMILES |
C1CCC(C1)(CNC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O)C(=O)O
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| InChI |
1S/C24H21N3O5/c25-13-19-18-12-16(32-15-6-2-1-3-7-15)8-9-17(18)21(28)20(27-19)22(29)26-14-24(23(30)31)10-4-5-11-24/h1-3,6-9,12,28H,4-5,10-11,14H2,(H,26,29)(H,30,31)
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| InChIKey |
JSYWJICQZNCWHF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
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| REF 1 | 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892. | |||
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