Drug Information
Drug General Information | Top | |||
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Drug ID |
D0W1WQ
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Former ID |
DNC005396
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Drug Name |
(R)-3-(4-Isobutyl-phenyl)-butan-2-one
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Synonyms |
2-Butanone,3-[4-(2-methylpropyl)phenyl]-,(3R)-; SCHEMBL4471196; CHEMBL371421; ZINC13646153
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C14H20O
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Canonical SMILES |
CC(C)CC1=CC=C(C=C1)C(C)C(=O)C
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InChI |
1S/C14H20O/c1-10(2)9-13-5-7-14(8-6-13)11(3)12(4)15/h5-8,10-11H,9H2,1-4H3/t11-/m0/s1
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InChIKey |
VOYZJYGIHFRNAG-NSHDSACASA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | C-X-C chemokine receptor type 1 (CXCR1) | Target Info | Inhibitor | [1] |
C-X-C chemokine receptor type 2 (CXCR2) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Chemokine signaling pathway | ||||
Endocytosis | ||||
Epithelial cell signaling in Helicobacter pylori infection | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
TNFalpha Signaling Pathway | ||||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Interleukin signaling pathway | ||||
Pathway Interaction Database | IL8- and CXCR1-mediated signaling events | |||
IL8- and CXCR2-mediated signaling events | ||||
Reactome | Chemokine receptors bind chemokines | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Differentiation Pathway | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. |
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