Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W2QN
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| Former ID |
DNC005763
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| Drug Name |
2-Ethyl-5-methoxy-3-piperidin-4-yl-1H-indole
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| Synonyms |
CHEMBL194412; 1h-indole,2-ethyl-5-methoxy-3-(4-piperidinyl)-; 866404-90-2; 2-Ethyl-5-methoxy-3-piperidin-4-yl-1H-indole; ZINC28526364; BDBM50171247
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H22N2O
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| Canonical SMILES |
CCC1=C(C2=C(N1)C=CC(=C2)OC)C3CCNCC3
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| InChI |
1S/C16H22N2O/c1-3-14-16(11-6-8-17-9-7-11)13-10-12(19-2)4-5-15(13)18-14/h4-5,10-11,17-18H,3,6-9H2,1-2H3
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| InChIKey |
UMTBQNCFQQORNJ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 6 receptor (HTR6) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4230-4. | |||
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