Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W5EH
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| Former ID |
DCL000973
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| Drug Name |
Sarizotan
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| Synonyms |
Sarizotan [INN]; EMD 128130; N-((3,4-Dihydro-2H-1-benzopyran-2-yl)methyl)-5-(4-fluorophenyl)-3-pyridinemethanamine; (-)-3-((((R)-2-Chromanylmethyl)amino)methyl)-5-(p-fluorophenyl)pyridine; 1-(3,4-dihydro-2H-chromen-2-yl)-N-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]methanamine
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| Drug Type |
Small molecular drug
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| Indication | Rett syndrome [ICD-11: LD90.4; ICD-10: F84.2] | Phase 2/3 | [1] | |
| Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Discontinued in Phase 2 | [2] | ||
| Company |
EMD Serono
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| Structure |
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Download2D MOL |
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| Formula |
C22H21FN2O
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| Canonical SMILES |
C1CC2=CC=CC=C2OC1CNCC3=CC(=CN=C3)C4=CC=C(C=C4)F
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| InChI |
1S/C22H21FN2O/c23-20-8-5-17(6-9-20)19-11-16(12-24-14-19)13-25-15-21-10-7-18-3-1-2-4-22(18)26-21/h1-6,8-9,11-12,14,21,25H,7,10,13,15H2/t21-/m1/s1
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| InChIKey |
HKFMQJUJWSFOLY-OAQYLSRUSA-N
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| CAS Number |
CAS 351862-32-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. | |||
| REF 3 | Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents.Curr Med Chem.2014;21(4):437-57. | |||
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