Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X2NO
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| Former ID |
DIB018062
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| Drug Name |
(+)-ADTN
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| Synonyms |
(+)-ADTN (aminotetralin-6,7-diol)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C10H13NO2
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| Canonical SMILES |
C1CC2=CC(=C(C=C2CC1N)O)O
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| InChI |
1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
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| InChIKey |
ASXGAOFCKGHGMF-UHFFFAOYSA-N
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| CAS Number |
CAS 53463-78-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4396597, 8152008, 11364921, 11367483, 11370045, 11373084, 11375645, 11378215, 15017255, 24714865, 26755674, 26755675, 29222295, 47365320, 47440382, 47515425, 47515426, 47662414, 47736607, 48035255, 48035256, 48185101, 50064875, 50111036, 50111037, 52533724, 57321638, 85208928, 90340878, 92310038, 99300950, 103197355, 103805117, 103925217, 104302678, 117616121, 124749696, 124879796, 124879797, 124879798, 124879799, 125570003, 126686686, 127454619, 132611435, 135072376, 135649897, 162866432, 163667276, 163882663
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D1 receptor (D1R) | Target Info | Agonist | [2] |
| Dopamine D5 receptor (D5R) | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Dopaminergic synapse | ||||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Morphine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Dopamine receptor mediated signaling pathway | |||
| Pathwhiz Pathway | Dopamine Activation of Neurological Reward System | |||
| Reactome | Dopamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Genes and (Common) Pathways Underlying Drug Addiction | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 932). | |||
| REF 2 | Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. | |||
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