Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X5UN
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| Former ID |
DNAP001695
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| Drug Name |
Mirabegron
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| Synonyms |
Myrbetriq (TN)
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| Drug Type |
Small molecular drug
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| Indication | Overactive bladder [ICD-11: GC50.0; ICD-10: N32.8] | Approved | [1], [2] | |
| Company |
Astellas
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H24N4O2S
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| Canonical SMILES |
C1=CC=C(C=C1)C(CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O
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| InChI |
1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
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| InChIKey |
PBAPPPCECJKMCM-IBGZPJMESA-N
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| CAS Number |
CAS 223673-61-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14830284, 15100038, 24157536, 45287794, 80776075, 96026215, 104179241, 131305973, 135262850, 135264045, 137204503, 141480260, 152258601, 160644771, 160647435, 160708387, 164178021, 164230555, 164763064, 172914174, 175267526, 175427137, 178104017, 186007037, 187072486, 188932513, 218903013, 223541479, 223664787, 223701034, 223917501, 227170942, 242060285, 248359277, 249867219, 251963956, 251971077, 252160992, 252227885, 252448538, 252553766
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| ChEBI ID |
CHEBI:65349
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| ADReCS Drug ID | BADD_D01475 | |||
| SuperDrug ATC ID |
G04BD12
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-3 (ADRB3) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Salivary secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta3 adrenergic receptor signaling pathway | ||||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7445). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
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