Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X5US
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| Former ID |
DIB020066
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| Drug Name |
IOX1
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| Synonyms |
5852-78-8; 8-Hydroxyquinoline-5-Carboxylic Acid; 8-Hydroxy-5-quinolinecarboxylic acid; 5-Carboxy-8-hydroxyquinoline; IOX 1; UNII-JM015YQC1C; IOX-1; 5-carboxy-8HQ; 5-Quinolinecarboxylic acid, 8-hydroxy-; JM015YQC1C; CHEMBL1230640; 4bio; 4jht; 8XQ; 4ie4; AC1LA0UV; MLS002729056; GTPL8230; SCHEMBL6068195; KS-00000PPH; CHEBI:93239; CTK1E0142; DTXSID20207236; AOB6499; JGRPKOGHYBAVMW-UHFFFAOYSA-N; MolPort-006-673-354; HMS3653E21; ZINC5933707; BCP16996; s7234; BDBM50396018; 2184AH; IOX1, > AKOS016371793
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C10H7NO3
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| Canonical SMILES |
C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
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| InChI |
1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
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| InChIKey |
JGRPKOGHYBAVMW-UHFFFAOYSA-N
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| CAS Number |
CAS 5852-78-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
610024, 24565020, 52213785, 85736331, 85736332, 90419359, 98533675, 99495762, 103022918, 103022919, 103061177, 104224071, 104246832, 109727243, 124349525, 128272379, 162023827, 162162974, 162249179, 163274271, 163345042, 163621616, 170474706, 170475767, 172648355, 190861987, 196395956, 198942941, 208012961, 208013114, 208013265, 210274788, 210280421, 218929531, 223404288, 225124590, 231825475, 249547744, 249565910, 249773725, 252141344, 252158083, 252260310, 252451420, 252470230
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| ChEBI ID |
CHEBI:93239
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Lysine-specific demethylase 3A (KDM3A) | Target Info | Inhibitor | [1] | |
| Lysine-specific demethylase 4C (KDM4C) | Target Info | Inhibitor | [1] | |
| Lysine-specific demethylase 6B (KDM6B) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. | |||
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