Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0XQ8P
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| Former ID |
DNC011972
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| Drug Name |
2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one
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| Synonyms |
2-(Thiazol-5-ylmethyl)-1H-indazol-3(2H)-one; 120273-62-3; CHEMBL3144715; 1,2-dihydro-2-(5-thiazolylmethyl)-3H-indazol-3-one; 2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one; CHEMBL267524; SCHEMBL16160907; BDBM50008996; ZINC100161259; AKOS022188370; AJ-64420; AJ-64421; AX8285840
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H9N3OS
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=O)N(N2)CC3=CN=CS3
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| InChI |
1S/C11H9N3OS/c15-11-9-3-1-2-4-10(9)13-14(11)6-8-5-12-7-16-8/h1-5,7,13H,6H2
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| InChIKey |
KPXSUQVYEHMEMW-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 5-lipoxygenase (5-LOX) | Target Info | Inhibitor | [1] |
| BioCyc | Aspirin-triggered lipoxin biosynthesis | |||
| Resolvin D biosynthesis | ||||
| Leukotriene biosynthesis | ||||
| Lipoxin biosynthesis | ||||
| Aspirin triggered resolvin D biosynthesis | ||||
| Aspirin triggered resolvin E biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Ovarian steroidogenesis | ||||
| Toxoplasmosis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. | |||
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