Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y0ER
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| Former ID |
DAP000315
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| Drug Name |
Thiethylperazine
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| Synonyms |
ETHYLTHIOPERAZINE; Theithylperazine; Thiethylperazinum; Thiethylpipezazine; Thioethylperazine; Tietilperazina; Torecan; Tietilperazina [DCIT]; Thiethylperazinum [INN-Latin]; Torecan (TN); Thiethylperazine (USAN/INN); Thiethylperazine [USAN:INN:BAN]; Norzine (*Dimaleate*); GS-95 (*Dimaleate*)
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| Drug Type |
Small molecular drug
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| Indication | Nausea [ICD-11: MD90; ICD-10: R11] | Approved | [1], [2] | |
| Therapeutic Class |
Antiemetics
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| Company |
Norvatis Phamaceuticals Corporation
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| Structure |
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Download2D MOL |
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| Formula |
C22H29N3S2
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| Canonical SMILES |
CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C
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| InChI |
1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
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| InChIKey |
XCTYLCDETUVOIP-UHFFFAOYSA-N
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| CAS Number |
CAS 1420-55-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9342, 618292, 5646731, 7849413, 7980773, 8153348, 10507857, 14879091, 29224490, 46506502, 48416610, 49699402, 50006536, 56352874, 57322781, 76368511, 85209578, 103462495, 104309248, 125089234, 125823178, 127339724, 127339725, 127339726, 134222490, 134337627, 134979014, 135739860, 137001505, 142971091, 160963719, 162939803, 178103879, 179116916, 184527123, 198985013, 226432954, 249932754, 251971089, 252655192
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| ChEBI ID |
CHEBI:9544
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| SuperDrug ATC ID |
R06AD03
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| SuperDrug CAS ID |
cas=001420559
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Prevotella copri
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Thiethylperazine dimalate (adjusted p-values: 4.54E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Coprococcus comes
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Thiethylperazine dimalate (adjusted p-values: 4.41E-03). | |||
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Studied Microbe: Eubacterium rectale
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Thiethylperazine dimalate (adjusted p-values: 1.76E-03). | |||
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Studied Microbe: Roseburia intestinalis
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Thiethylperazine dimalate (adjusted p-values: 4.54E-03). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7306). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012753. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Antiemetic specificity of dopamine antagonists. Psychopharmacology (Berl). 1982;78(3):210-3. | |||
| REF 5 | Torecan-induced neuroleptic malignant syndrome. Harefuah. 1990 May 15;118(10):576-8. | |||
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