Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y2JI
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| Former ID |
DIB021240
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| Drug Name |
xylazine
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| Synonyms |
Bayer 1470; Narcoxyl; Rompun; Xylapan; Xylasol; Xylzin; BAY-VA-1470
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C12H16N2S
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| Canonical SMILES |
CC1=C(C(=CC=C1)C)NC2=NCCCS2
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| InChI |
1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
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| InChIKey |
BPICBUSOMSTKRF-UHFFFAOYSA-N
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| CAS Number |
CAS 7361-61-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3712514, 6134291, 6383461, 8149776, 8153496, 10321871, 11111970, 11111971, 11335624, 11360863, 11364161, 11366723, 11369285, 11372622, 11374076, 11377447, 11461835, 11466626, 11467746, 11485051, 11486431, 11489264, 11491287, 11492054, 11495081, 14797946, 24902128, 26612232, 26679606, 26747186, 26747187, 26752277, 29224744, 47216724, 47291083, 47440194, 47440195, 47440196, 47588946, 47588947, 47662224, 47959679, 48334433, 49698575, 50051422, 50085432, 50105055, 50532260, 53837769, 57322904
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| ChEBI ID |
CHEBI:92386
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Agonist | [2] |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Agonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Integration of energy metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 523). | |||
| REF 2 | Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol. 1998 Apr 1;55(7):1035-43. | |||
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