Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y3NI
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| Drug Name |
US8921389, 123
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| Synonyms |
SCHEMBL12502342; CHEMBL3639708; CJDQJFHCXLGXOK-UHFFFAOYSA-N; BDBM141666; US8921389, 123; 3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenethyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C27H25N3O5
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| Canonical SMILES |
C1=CC=C(C=C1)CCC2=CC3=C(C(=NC=C3N(C2=O)CC4=CC=CC=C4)C(=O)NCCC(=O)O)O
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| InChI |
1S/C27H25N3O5/c31-23(32)13-14-28-26(34)24-25(33)21-15-20(12-11-18-7-3-1-4-8-18)27(35)30(22(21)16-29-24)17-19-9-5-2-6-10-19/h1-10,15-16,33H,11-14,17H2,(H,28,34)(H,31,32)
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| InChIKey |
CJDQJFHCXLGXOK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
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| REF 1 | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase. US8921389. | |||
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