Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y6SN
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| Former ID |
DCL000976
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| Drug Name |
SB-277011
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| Synonyms |
SB 277011; SB 277011A; SB 277011-A; N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Terminated | [1], [2] | |
| Company |
GlaxoSmithKline
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| Structure |
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Download2D MOL |
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| Formula |
C28H30N4O
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| Canonical SMILES |
C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
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| InChI |
1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)
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| InChIKey |
OLWRVVHPJFLNPW-UHFFFAOYSA-N
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| CAS Number |
CAS 215803-78-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7979281, 14759237, 39340816, 47731229, 48329042, 50075888, 56210210, 57359353, 77302121, 85209431, 103291265, 103857948, 104053095, 104133783, 114155250, 125329835, 125647247, 128827839, 128827840, 131305404, 134222959, 135323990, 135651003, 137144216, 152043734, 152258270, 160647107, 160849674, 162011819, 164233548, 164764956, 170485706, 174528353, 179293940, 186014801, 229146917, 229146923, 251963242, 252670316
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D3 receptor (D3R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Dopaminergic synapse | ||||
| Reactome | Dopamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 143). | |||
| REF 2 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. | |||
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