Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Y8DJ
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Former ID |
DNC012117
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Drug Name |
(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol
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Synonyms |
63006-93-9; (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol; 1,2,3,4-Tetrahydroisoquinoline-3-methanol; (1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol; 1,2,3,4-tetrahydroisoquinolin-3-ylmethanol; (S)-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol; 62928-94-3; CHEMBL60068; 1,2,3,4-tetrahydro-3-isoquinolinemethanol; 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-; 3-Hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; F2147-1627; PubChem5794; AC1MWNWL; (S)-1,2,3,4-Tetrahydroisoquinolylmethan-3-ol; ACMC-209err; ChemDiv2_003241
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C10H13NO
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Canonical SMILES |
C1C(NCC2=CC=CC=C21)CO
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InChI |
1S/C10H13NO/c12-7-10-5-8-3-1-2-4-9(8)6-11-10/h1-4,10-12H,5-7H2
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InChIKey |
ZSKDXMLMMQFHGW-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
KEGG Pathway | cGMP-PKG signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Reactome | Adrenoceptors | |||
Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
Adrenaline,noradrenaline inhibits insulin secretion | ||||
G alpha (i) signalling events | ||||
G alpha (z) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
Platelet Aggregation (Plug Formation) | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. |
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