Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z2MB
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| Former ID |
DCL000087
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| Drug Name |
Cilansetron
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| Synonyms |
Calmactin; DU-123265; KC-9946; Cilansetron (USAN/INN)
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| Drug Type |
Small molecular drug
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| Indication | Irritable bowel syndrome [ICD-11: DD91.0; ICD-10: K55-K64, K58; ICD-9: 564.1, 787.91] | Phase 3 | [1], [2] | |
| Company |
Solvay Pharma
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H21N3O
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| Canonical SMILES |
CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC5=C4N3CCC5
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| InChI |
1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3/t15-/m1/s1
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| InChIKey |
NCNFDKWULDWJDS-OAHLLOKOSA-N
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| CAS Number |
CAS 120635-74-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| SuperDrug ATC ID |
A03AE03
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Modulator | [3] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2297). | |||
| REF 2 | Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. | |||
| REF 3 | Cilansetron: a new serotonergic agent for the irritable bowel syndrome with diarrhoea.Expert Opin Investig Drugs.2005 Feb;14(2):185-93. | |||
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