Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z2WQ
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| Former ID |
DNC001183
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| Drug Name |
Quinelorane
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| Synonyms |
Quinelorane; Quinelorane [INN:BAN]; Quineloranum [INN-Latin]; UNII-Z0X4VT3Y1Q; Quinelorano [INN-Spanish]; 97466-90-5; Z0X4VT3Y1Q; LY 163502; LY 137157; LY 175877; CHEMBL155731; (5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine; (5aR-trans)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido(2,3-g)quinazolin-2-amine; Pyrido(2,3-g)quinazolin-2-amine, 5,5a,6,7,8,9,9a,10-octahydro-6-propyl-, (5aR-trans)-; DSSTox_RID_81533; DSSTox_CID_26315; DSSTox_GSID_46315; Quineloranum; Quinelorano; CAS-97466-90-5
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| Drug Type |
Small molecular drug
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| Indication | Male sexual disorder [ICD-11: HA02.0] | Discontinued in Phase 3 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H22N4
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| Canonical SMILES |
CCCN1CCCC2C1CC3=CN=C(N=C3C2)N
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| InChI |
1S/C14H22N4/c1-2-5-18-6-3-4-10-7-12-11(8-13(10)18)9-16-14(15)17-12/h9-10,13H,2-8H2,1H3,(H2,15,16,17)/t10-,13-/m1/s1
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| InChIKey |
TUFADSGTJUOBEH-ZWNOBZJWSA-N
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| CAS Number |
CAS 97466-90-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8185128, 11111703, 14823336, 15196615, 43114956, 47349364, 47646566, 47795046, 48169381, 50035171, 51048994, 57309569, 85788352, 90341289, 103405082, 103927698, 104312139, 124750174, 124892377, 135014815, 135650871, 135696152, 135749149, 137036431, 141724360, 144205562, 162223515, 170466296, 179151490, 184547243, 198951792, 226709836
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| ChEBI ID |
CHEBI:92230
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D3 receptor (D3R) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Dopaminergic synapse | ||||
| Reactome | Dopamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 954). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001472) | |||
| REF 3 | Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies.Pharmacol Biochem Behav.2008 Oct;90(4):686-90. | |||
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