Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z3ZZ
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| Former ID |
DNC014519
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| Drug Name |
(+/-)-2-Methyl-1-(1-phenylethyl)-1H-imidazole
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| Synonyms |
Efetozole; CHEMBL1269155; Efetozole [INN]; 2-methyl-1-(1-phenylethyl)-1H-imidazole; AC1L4LLD; (+/-)-2-Methyl-1-(1-phenylethyl)-1H-imidazole; SCHEMBL2109012; MolPort-020-890-666; CGP-22364A; BDBM50330055; 2-methyl-1-(1-phenylethyl)imidazole; AKOS013440375; 90408-21-2; (+-)-2-Methyl-1-(alpha-methylbenzyl)imidazole; (- )-2-Methyl-1-(alpha-methylbenzyl)imidazole.
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H14N2
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| Canonical SMILES |
CC1=NC=CN1C(C)C2=CC=CC=C2
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| InChI |
1S/C12H14N2/c1-10(12-6-4-3-5-7-12)14-9-8-13-11(14)2/h3-10H,1-2H3
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| InChIKey |
CILDGVODBJAMGO-UHFFFAOYSA-N
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| CAS Number |
CAS 99500-54-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nitric-oxide synthase brain (NOS1) | Target Info | Inhibitor | [1] |
| BioCyc | Citrulline-nitric oxide cycle | |||
| KEGG Pathway | Arginine and proline metabolism | |||
| Metabolic pathways | ||||
| Calcium signaling pathway | ||||
| Phagosome | ||||
| Circadian entrainment | ||||
| Long-term depression | ||||
| Salivary secretion | ||||
| Alzheimer's disease | ||||
| Amyotrophic lateral sclerosis (ALS) | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Panther Pathway | CCKR signaling map ST | |||
| Pathwhiz Pathway | Arginine and Proline Metabolism | |||
| Reactome | ROS production in response to bacteria | |||
| Nitric oxide stimulates guanylate cyclase | ||||
| WikiPathways | Monoamine Transport | |||
| Myometrial Relaxation and Contraction Pathways | ||||
| Amyotrophic lateral sclerosis (ALS) | ||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | ||||
| Spinal Cord Injury | ||||
| Alzheimers Disease | ||||
| Effects of Nitric Oxide | ||||
| Serotonin Transporter Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. | |||
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