Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z6DE
|
|||
| Former ID |
DCL000967
|
|||
| Drug Name |
RPSGL-Ig
|
|||
| Indication | Delayed graft function [ICD-11: 4B24.0; ICD-10: T86; ICD-9: 996] | Phase 2 | [1] | |
| Company |
Thios Pharmaceuticals
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P-selectin (SELP) | Target Info | Inhibitor | [1], [2] |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| Malaria | ||||
| Staphylococcus aureus infection | ||||
| Pathway Interaction Database | IL4-mediated signaling events | |||
| amb2 Integrin signaling | ||||
| Reactome | Platelet degranulation | |||
| Cell surface interactions at the vascular wall | ||||
| WikiPathways | Human Complement System | |||
| Spinal Cord Injury | ||||
| Cell surface interactions at the vascular wall | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. | |||
| REF 2 | rPSGL-1-Ig, a recombinant PSGL-1-Ig fusion protein, ameliorates LPS-induced acute lung injury in mice by inhibiting neutrophil migration. Cell Mol Biol (Noisy-le-grand). 2015 Feb 28;61(1):1-6. | |||
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