Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ZG3D
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| Drug Name |
PMID29649907-Compound-30
|
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| Drug Type |
Small molecular drug
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| Company |
SALK INSTITUTE FOR BIOLOGICAL STUDIE
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| Structure |
 |
Download2D MOL |
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| Formula |
C32H32FN3O3
|
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| Canonical SMILES |
CN1C2=C(C=C(C=C2)C3=CC(=C(C=C3)CN(C4=CC=CC(=C4)C=CC(=O)OC)C(=O)C5CCCCC5)F)C=N1
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| InChI |
1S/C32H32FN3O3/c1-35-30-15-14-24(18-27(30)20-34-35)25-12-13-26(29(33)19-25)21-36(32(38)23-8-4-3-5-9-23)28-10-6-7-22(17-28)11-16-31(37)39-2/h6-7,10-20,23H,3-5,8-9,21H2,1-2H3/b16-11+/i21D
|
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| InChIKey |
NOJHCAUXLPQOOD-STTMTRHISA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
| Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
| KEGG Pathway | Bile secretion | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Recycling of bile acids and salts | |||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. | |||
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