Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ZT8D
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| Former ID |
DNC012052
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| Drug Name |
Tramazoline
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| Synonyms |
Tramazoline; 1082-57-1; UNII-SLE31693IV; Towk; CHEMBL32573; SLE31693IV; QQJLHRRUATVHED-UHFFFAOYSA-N; 4,5-Dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-1H-imidazol-2-amine; Rhinol; 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-; N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine; Tramazolina; Rhynaspray; Tramazolinum; Tobispray; Tramazoline [INN:BAN]; Tramazolinum [INN-Latin]; Tramazolina [INN-Spanish]; Muconasal (TN); EINECS 214-105-6; Tramazoline (INN); TRAMAZOLIN; AC1Q4UQJ; AC1L1KJB
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C13H17N3
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| Canonical SMILES |
C1CCC2=C(C1)C=CC=C2NC3=NCCN3
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| InChI |
1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16)
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| InChIKey |
QQJLHRRUATVHED-UHFFFAOYSA-N
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| CAS Number |
CAS 1082-57-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:134893
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| ADReCS Drug ID | BADD_D02256 | |||
| SuperDrug ATC ID |
R01AA09
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. | |||
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