Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D1BCW8
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| Drug Name |
APY29
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| Synonyms |
1216665-49-4; APY 29; APY-29; N~2~-1h-Benzimidazol-5-Yl-N~4~-(3-Cyclopropyl-1h-Pyrazol-5-Yl)pyrimidine-2,4-Diamine; N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine; N2-(1H-benzo[d]imidazol-6-yl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; (E)-N-(6-((5-cyclopropyl-1H-pyrazol-3-yl)imino)-1,6-dihydropyrimidin-2-yl)-1H-benzo[d]imidazol-6-amine; APY 29;APY-29; CHEMBL1231018; SCHEMBL12045464; SCHEMBL20438003; SCHEMBL21067744; EX-A305; BCP09071; MFCD28023582; s6623; ZINC40163635; AKOS024458384; DB07382; 2-N-(3H-benzimidazol-5-yl)-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; NCGC00379217-02; NCGC00379217-03; AK547105; BS-14553; DA-47145; HY-17537; QC-11386; AB0098417; FT-0700119; J3.589.967G; Q27096602; 2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H16N8
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| Canonical SMILES |
C1CC1C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)N=CN5
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| InChI |
1S/C17H16N8/c1-2-10(1)13-8-16(25-24-13)22-15-5-6-18-17(23-15)21-11-3-4-12-14(7-11)20-9-19-12/h3-10H,1-2H2,(H,19,20)(H3,18,21,22,23,24,25)
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| InChIKey |
WJNBSTLIALIIEW-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endoplasmic reticulum to nucleus signaling 1 (ERN1) | Target Info | Inhibitor | [2] |
| References | Top | |||
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| REF 1 | Allosteric inhibition of the IRE1alpha RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31;158(3):534-48. | |||
| REF 2 | Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. Food Chem Toxicol. 2018 Apr;114:52-60. | |||
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