Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DJN3E2
|
|||
| Drug Name |
mRNA-3704
|
|||
| Drug Type |
mRNA therapy
|
|||
| Indication | Methylmalonic acidemia [ICD-11: 5C50.E0] | Phase 1/2 | [1] | |
| Company |
Moderna Therapeutics
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Methylmalonyl-CoA mutase (MMUT) | Target Info | Replacement | [2] |
| BioCyc | Superpathway of methionine degradation | |||
| Propionyl-CoA degradation | ||||
| 2-oxobutanoate degradation | ||||
| KEGG Pathway | Valine, leucine and isoleucine degradation | |||
| Glyoxylate and dicarboxylate metabolism | ||||
| Propanoate metabolism | ||||
| Metabolic pathways | ||||
| Carbon metabolism | ||||
| Panther Pathway | Methylmalonyl pathway | |||
| Succinate to proprionate conversion | ||||
| Pathwhiz Pathway | Valine, Leucine and Isoleucine Degradation | |||
| Propanoate Metabolism | ||||
| Threonine and 2-Oxobutanoate Degradation | ||||
| Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | |||
| WikiPathways | Metabolism of water-soluble vitamins and cofactors | |||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| Vitamin B12 Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03810690) Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Moderna Therapeutics. | |||
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