Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DKUF26
|
|||
| Drug Name |
SL-172154
|
|||
| Drug Type |
Recombinant protein
|
|||
| Indication | Ovarian cancer [ICD-11: 2C73; ICD-10: C56; ICD-9: 183] | Phase 1 | [1] | |
| Company |
Shattuck Labs
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CD40L receptor (CD40) | Target Info | Inhibitor | [2] |
| Leukocyte surface antigen CD47 (CD47) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| NF-kappa B signaling pathway | ||||
| Cell adhesion molecules (CAMs) | ||||
| Toll-like receptor signaling pathway | ||||
| Intestinal immune network for IgA production | ||||
| Malaria | ||||
| Toxoplasmosis | ||||
| HTLV-I infection | ||||
| Epstein-Barr virus infection | ||||
| Transcriptional misregulation in cancer | ||||
| Asthma | ||||
| Autoimmune thyroid disease | ||||
| Systemic lupus erythematosus | ||||
| Allograft rejection | ||||
| Primary immunodeficiency | ||||
| Viral myocarditis | ||||
| Pathway Interaction Database | CD40/CD40L signaling | |||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Inflammatory Response Pathway | ||||
| NLR Proteins | ||||
| Vitamin D Receptor Pathway | ||||
| Human Complement System | ||||
| Allograft Rejection | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04406623) Phase 1 Study of SL-172154 (SIRPalpha-Fc-CD40L) in Subjects With Ovarian Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Shattuck Labs. | |||
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