| Target and Pathway |
Top |
| Target(s) |
Protein-tyrosine phosphatase SHP-2 (PTPN11) |
Target Info
|
Inhibitor |
[2] |
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KEGG Pathway
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Ras signaling pathway
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Jak-STAT signaling pathway
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Natural killer cell mediated cytotoxicity
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Leukocyte transendothelial migration
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Neurotrophin signaling pathway
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Adipocytokine signaling pathway
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Epithelial cell signaling in Helicobacter pylori infection
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Herpes simplex infection
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Proteoglycans in cancer
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Renal cell carcinoma
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Chronic myeloid leukemia
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NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
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Panther Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Fc-epsilon receptor I signaling in mast cells
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Insulin Pathway
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GMCSF-mediated signaling events
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TCR signaling in naï
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events regulated by Ret tyrosine kinase
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Angiopoietin receptor Tie2-mediated signaling
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SHP2 signaling
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IL2-mediated signaling events
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CXCR4-mediated signaling events
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IGF1 pathway
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EGF receptor (ErbB1) signaling pathway
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IL5-mediated signaling events
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IL2 signaling events mediated by PI3K
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Integrins in angiogenesis
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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PDGFR-beta signaling pathway
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Neurotrophic factor-mediated Trk receptor signaling
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VEGFR1 specific signals
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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IL2 signaling events mediated by STAT5
|
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Signaling events mediated by VEGFR1 and VEGFR2
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N-cadherin signaling events
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FGF signaling pathway
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Reactome
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Interleukin-6 signaling
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PI3K Cascade
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MAPK3 (ERK1) activation
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MAPK1 (ERK2) activation
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GPVI-mediated activation cascade
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Prolactin receptor signaling
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PIP3 activates AKT signaling
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Spry regulation of FGF signaling
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GAB1 signalosome
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PECAM1 interactions
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Tie2 Signaling
|
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Constitutive Signaling by Aberrant PI3K in Cancer
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Costimulation by the CD28 family
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CTLA4 inhibitory signaling
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PD-1 signaling
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Signal regulatory protein (SIRP) family interactions
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Netrin mediated repulsion signals
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Platelet sensitization by LDL
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Interleukin-3, 5 and GM-CSF signaling
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PI-3K cascade:FGFR1
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FRS-mediated FGFR1 signaling
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PI-3K cascade:FGFR2
|
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SHC-mediated cascade:FGFR2
|
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FRS-mediated FGFR2 signaling
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FRS-mediated FGFR3 signaling
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PI-3K cascade:FGFR3
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FRS-mediated FGFR4 signaling
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SHC-mediated cascade:FGFR4
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PI-3K cascade:FGFR4
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Negative regulation of FGFR1 signaling
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Negative regulation of FGFR2 signaling
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Negative regulation of FGFR3 signaling
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Negative regulation of FGFR4 signaling
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Regulation of IFNG signaling
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Interferon alpha/beta signaling
|
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Regulation of IFNA signaling
|
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Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
|
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WikiPathways
|
TCR Signaling Pathway
|
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Type II interferon signaling (IFNG)
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Interferon type I signaling pathways
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IL-2 Signaling Pathway
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Insulin Signaling
|
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EGF/EGFR Signaling Pathway
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IL-4 Signaling Pathway
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IL-6 signaling pathway
|
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Signaling of Hepatocyte Growth Factor Receptor
|
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Kit receptor signaling pathway
|
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IL-3 Signaling Pathway
|
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MyD88-independent cascade
|
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Signaling by SCF-KIT
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Interleukin-6 signaling
|
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Prolactin receptor signaling
|
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
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PIP3 activates AKT signaling
|
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JAK/STAT
|
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PDGF Pathway
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Alpha 6 Beta 4 signaling pathway
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BDNF signaling pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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B Cell Receptor Signaling Pathway
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Prostate Cancer
|
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Pilocytic astrocytoma
|
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TSLP Signaling Pathway
|
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Leptin signaling pathway
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IL-1 signaling pathway
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Signaling by PDGF
|
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Signaling by FGFR
|
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Signaling by EGFR
|
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Signal regulatory protein (SIRP) family interactions
|
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Platelet homeostasis
|
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Netrin-1 signaling
|
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Interleukin-3, 5 and GM-CSF signaling
|
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Interferon alpha/beta signaling
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Costimulation by the CD28 family
|
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Cell surface interactions at the vascular wall
|
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Heart Development
|
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IL-5 Signaling Pathway
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