miRNA General Information
miRNA Mature ID hsa-miR-30d-5p
miRNA Stemloop AC MI0000255
miRNA Stemloop ID hsa-mir-30d
Sequence uguaaacauccccgacuggaag
TTD Target(s) Regulated by This miRNA Caspase-3 (CASP3) Clinical trial Target Target Info [1]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [2]
Enhancer of zeste homolog 2 (EZH2) Successful Target Target Info [3]
Notch-1 receptor (NOTCH1) Clinical trial Target Target Info [4]
MEK kinase kinase 4 (MAP4K4) Patented-recorded Target Target Info [5]
Importin beta (KPNB1) Literature-reported Target Target Info [6]
Autophagy-related 2B (ATG2B) Literature-reported Target Target Info [7]
Beclin-1 (BECN1) Literature-reported Target Target Info [7]
Runt-related transcription factor 2 (RUNX2) Literature-reported Target Target Info [8]
Suppressor of cytokine signaling 1 (SOCS1) Literature-reported Target Target Info [9]
Protein(s) Regulated by This miRNA Autophagy protein 5 Regulated Protein [7]
B-cell CLL/lymphoma 9 protein Regulated Protein [11]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Regulated Protein [7]
G-protein coupled receptor 78 Regulated Protein [12]
Guanine nucleotide-binding protein G(i) subunit alpha-2 Regulated Protein [13]
LIM and senescent cell antigen-like-containing domain protein 1 Regulated Protein [5]
Phosphatidylinositol 3-kinase regulatory subunit beta Regulated Protein [15]
Protein phosphatase 1 regulatory subunit 14C Regulated Protein [5]
Ubiquitin-like protein ATG12 Regulated Protein [7]
Zinc finger protein SNAI1 Regulated Protein [16]
References
REF 1 A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer. Cancer Res. 2012 Jan 1;72(1):154-64.
REF 2 Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene. 2011 Feb 17;30(7):843-53.
REF 3 Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2. J Clin Endocrinol Metab. 2012 May;97(5):E710-8.
REF 4 Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids. J Am Soc Nephrol. 2014 Jan;25(1):92-104.
REF 5 Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study. Circulation. 2015 Jun 23;131(25):2202-2216.
REF 6 EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. J Pathol. 2014 Feb;232(3):308-18.
REF 7 mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun. 2013 Feb 15;431(3):617-22.
REF 8 Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol. 2011 Jul 18;12(7):R64.
REF 9 The viral and cellular microRNA targetome in lymphoblastoid cell lines. PLoS Pathog. 2012 Jan;8(1):e1002484.
REF 10 mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun. 2013 Feb 15;431(3):617-22.
REF 11 miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/-catenin/BCL9 pathway.Cancer Res. 2014 Mar 15;74(6):1801-13.
REF 12 miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.Oncogene. 2013 Sep 26;32(39):4694-701.
REF 13 MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma.Hepatology. 2010 Mar;51(3):846-56.
REF 14 Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study. Circulation. 2015 Jun 23;131(25):2202-2216.
REF 15 Regulation of Insulin Resistance by Multiple MiRNAs via Targeting the GLUT4 Signalling Pathway. Cell Physiol Biochem. 2016;38(5):2063-78.
REF 16 MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer.Int J Cancer. 2012 May 1;130(9):2044-53.

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