miRNA General Information
miRNA Mature ID hsa-miR-490-3p
miRNA Stemloop AC MI0003125
miRNA Stemloop ID hsa-mir-490
Sequence caaccuggaggacuccaugcug
TTD Target(s) Regulated by This miRNA TGF-beta receptor type I (TGFBR1) Clinical trial Target Target Info [1]
G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Target Info [2]
Transforming growth factor alpha (TGFA) Clinical trial Target Target Info [3]
Tankyrase-2 (TNKS-2) Clinical trial Target Target Info [4]
Transforming protein RhoA (RHOA) Discontinued Target Target Info [5]
Multidrug resistance-associated protein 2 (ABCC2) Literature-reported Target Target Info [6]
High mobility group protein HMGI-C (HMGA2) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Endoplasmic reticulum-Golgi intermediate compartment protein 3 Regulated Protein [8]
Pappalysin-1 Regulated Protein [9]
Poly(rC)-binding protein 1 Regulated Protein [10]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Regulated Protein [11]
REF 1 MicroRNA-490-3p inhibits colorectal cancer metastasis by targeting TGFR1. BMC Cancer. 2015 Dec 29;15:1023.
REF 2 MicroRNA-490-3p inhibits proliferation of A549 lung cancer cells by targeting CCND1. Biochem Biophys Res Commun. 2014 Jan 31;444(1):104-8.
REF 3 The correlation between microRNA490-3p and TGF in endometrial carcinoma tumorigenesis and progression. Oncotarget. 2016 Feb 23;7(8):9236-49.
REF 4 miR-490-3p inhibits the growth and invasiveness in triple-negative breast cancer by repressing the expression of TNKS2. Gene. 2016 Nov 15;593(1):41-47.
REF 5 MicroRNA-490 inhibits tumorigenesis and progression in breast cancer. Onco Targets Ther. 2016 Jul 22;9:4505-16.
REF 6 MiR-490-3p sensitizes ovarian cancer cells to cisplatin by directly targeting ABCC2. Am J Transl Res. 2017 Mar 15;9(3):1127-1138.
REF 7 MicroRNA-490-3p regulates cell proliferation and apoptosis by targeting HMGA2 in osteosarcoma. FEBS Lett. 2015 Oct 7;589(20 Pt B):3148-53.
REF 8 miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3).J Biol Chem. 2013 Feb 8;288(6):4035-47.
REF 9 MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A.Cardiovasc Res. 2013 Nov 1;100(2):272-9.
REF 10 Poly r(C) binding protein (PCBP) 1 is a negative regulator of thyroid carcinoma. Am J Transl Res. 2016 Aug 15;8(8):3567-73.
REF 11 Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis.Cancer Res. 2015 Feb 15;75(4):754-65.

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