miRNA General Information
miRNA Mature ID hsa-miR-663a
miRNA Stemloop AC MI0003672
miRNA Stemloop ID hsa-mir-663a
Sequence aggcggggcgccgcgggaccgc
TTD Target(s) Regulated by This miRNA PI3-kinase delta (PIK3CD) Successful Target Target Info [1]
C-X-C chemokine receptor type 4 (CXCR4) Successful Target Target Info [2]
Transforming growth factor beta 1 (TGFB1) Successful Target Target Info [3]
Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Target Info [4]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [5]
Kruppel like factor 4 (KLF4) Clinical trial Target Target Info [6]
Perlecan (HSPG) Discontinued Target Target Info [7]
Large neutral amino acids transporter 1 (SLC7A5) Literature-reported Target Target Info [6]
CCAAT/enhancer binding protein beta (CEBPB) Literature-reported Target Target Info [6]
GTPase HRas (HRAS) Literature-reported Target Target Info [8]
Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Target Info [9]
Protein(s) Regulated by This miRNA Adenomatous polyposis coli protein Regulated Protein [10]
Elongation factor 1-alpha 2 Regulated Protein [11]
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Regulated Protein [12]
Myosin regulatory light polypeptide 9 Regulated Protein [13]
Neuron navigator 2 Regulated Protein [6]
Protein fosB Regulated Protein [6]
Transcription elongation factor A protein-like 1 Regulated Protein [15]
Transcription factor jun-B Regulated Protein [16]
Transcription factor jun-D Regulated Protein [16]
REF 1 Primate-specific miR-663 functions as a tumor suppressor by targeting PIK3CD and predicts the prognosis of human glioblastoma. Clin Cancer Res. 2014 Apr 1;20(7):1803-13.
REF 2 miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway. BMC Cancer. 2017 Jan 7;17(1):33.
REF 3 MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation. Asian Pac J Cancer Prev. 2011;12(11):2819-23.
REF 4 Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells. Oncol Rep. 2010 Jul;24(1):105-12.
REF 5 ZNF224, Krpel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a. Oncotarget. 2016 May 24;7(21):31177-90.
REF 6 MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1762-9.
REF 7 The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2). J Biol Chem. 2013 Apr 19;288(16):10973-85.
REF 8 The epigenetically-regulated miR-663 targets H-ras in K-562 cells. FEBS J. 2013 Oct;280(20):5109-17.
REF 9 TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network. Genome Res. 2016 Mar;26(3):331-41.
REF 10 Downregulation of adenomatous polyposis coli by microRNA-663 promotes odontogenic differentiation through activation of Wnt/beta-catenin signaling.Biochem Biophys Res Commun. 2014 Apr 18;446(4):894-900.
REF 11 Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744.Br J Cancer. 2013 Jun 11;108(11):2304-11.
REF 12 Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach.Cell Biol Toxicol. 2016 Aug;32(4):285-303.
REF 13 MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation.Circ Res. 2013 Oct 25;113(10):1117-27.
REF 14 MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1762-9.
REF 15 MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma.Oncogene. 2012 Oct 11;31(41):4421-33.
REF 16 Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.Carcinogenesis. 2010 Sep;31(9):1561-6.

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