miRNA General Information
miRNA Mature ID hsa-miR-874-3p
miRNA Stemloop AC MI0005532
miRNA Stemloop ID hsa-mir-874
Sequence cugcccuggcccgagggaccga
TTD Target(s) Regulated by This miRNA Histone deacetylase 1 (HDAC1) Successful Target Target Info [1]
Signal transducer and activator of transcription 3 (STAT3) Successful Target Target Info [2]
Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Target Info [3]
Rotamase Pin1 (PIN1) Clinical trial Target Target Info [4]
Protein(s) Regulated by This miRNA Aquaporin-3 Regulated Protein [5]
Aquaporin-3 Regulated Protein [6]
REF 1 Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma. Br J Cancer. 2013 Apr 30;108(8):1648-58.
REF 2 miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. Oncotarget. 2015 Jan 30;6(3):1605-17.
REF 3 MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9. FEBS Lett. 2014 Dec 20;588(24):4527-35.
REF 4 miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression. Oncotarget. 2017 Feb 14;8(7):11343-11355.
REF 5 miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer.J Gastroenterol. 2014 Jun;49(6):1011-25.
REF 6 MiR-874 promotes intestinal barrier dysfunction through targeting AQP3 following intestinal ischemic injury.FEBS Lett. 2014 Mar 3;588(5):757-63.

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