Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02551 | Target Info | |||
| Target Name | Dopamine D3 receptor (D3R) | ||||
| Synonyms | D(3) dopamine receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | DRD3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2014180165 | ||||
| Title | Benzoisothiazole Compounds and Use In Preparation of Antipsychotic Drugs. | ||||
| Abstract | Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D3 receptor, 5-HT1A receptor and 5-HT2A receptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof. | ||||
| Applicant(s) | Shanghai Inst Pharm Industry | ||||
| Representative Drug(s) | D0M1UF | Drug Info | Ki = 0.13 nM | Click to Show More | [1] |
| 2 | D0Z9WY | Drug Info | Ki = 0.71 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. | ||||
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