Target and Its Patented Drug(s)
Target General Information | Top | ||||
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Target ID | T16691 | Target Info | |||
Target Name | 5-HT 6 receptor (HTR6) | ||||
Synonyms | Serotonin receptor 6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6; 5-HT-6 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | HTR6 | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID |
Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
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World Intellectual Property Organization (WIPO) | |||||
Patent ID | WO2016003296 | ||||
Title | (Quinoline or Isoquinoline)Sulfonamides of Cyclic Amines As Antipsychotic Drugs. | ||||
Abstract | The invention relates to compounds of general formula (I) wherein: one of A1 and A2 represents a nitrogen atom and the other a carbon atom optionally substituted by halogen; the wave line between the sulfonamido moiety and B/C rings represents a single bond linking the sulfur atom to a non-bridgehead carbon atom, with the proviso that the part of ring C being detached by the dashed broken line is unsubstituted; n represents an integer from 0 to 3; Y represents a nitrogen or carbon atom; Z represents a 5-6 membered aromatic/ heteroaromatic ring optionally fused with a further aromatic or non- aromatic 5-6 membered heterocycle, the condensed ring system being linked via a non-bridgehead carbon atom. The compounds display high affinity for the D2, D3, 5-HT1A, 5-HT2A- 5-HT6 and 5-HT7 receptors and are useful for the treatment of psychotropic diseases or disorders associated with disturbances of the dopaminergic/ serotoninergic systems such as schizophrenia and autism. | ||||
Applicant(s) | Instytut Farmakologii Polskiej Akademii Nauk | ||||
Representative Drug(s) | D0F4NB | Drug Info | Ki = 116 nM | Click to Show More | [1] |
2 | D09BCJ | Drug Info | Ki = 3264 nM | [1] |
References | Top | ||||
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REF 1 | 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. |
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