Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T40954 Target Info
Target Name Xanthine dehydrogenase/oxidase (XDH)
Synonyms Xanthine oxidase; Xanthine dehydrogenase; XDHA
Target Type Successful Target
Gene Name XDH
Biochemical Class CH/CH(2) oxidoreductase
UniProt ID
XDH_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US8877260
Title Use of Acacia Extracts and Their Compounds On Inhibition of Xanthine Oxidase.
Applicant(s) National Taiwan University
Representative Drug(s) D0J0JH Drug Info IC50 = 74 nM Click to Show More [1]
2 D0S0EM Drug Info IC50 = 270 nM [1]
Patent ID US8729273
Title Compounds Effective Asxanthine Oxidase Inhibitors, Methods for Preparing The Same and Pharmaceutical Composition Containing The Same.
Applicant(s) Lg Life Sciences Ltd
Representative Drug(s) D0Z2IO Drug Info IC50 = 2.1 nM Click to Show More [1]
2 D0AJ5T Drug Info IC50 = 2.8 nM [1]
3 D0EZ5O Drug Info IC50 = 3.4 nM [1]
Patent ID US8414936
Title Use of Acacia Extracts and Their Compounds On Inhibition of Xanthine Oxidase.
Applicant(s) National Taiwan University
Representative Drug(s) D0J0JH Drug Info IC50 = 74 nM Click to Show More [1]
2 D0S0EM Drug Info IC50 = 270 nM [1]
Patent ID US0296537
Title Fused Heterocyclic Derivative and Pharmaceutical Use Thereof.
Applicant(s) Kissei Pharmaceutical Co. Ltd
Representative Drug(s) D08KAT Drug Info IC50 = 10 nM Click to Show More [1]
2 D0N0MV Drug Info IC50 = 10 nM [1]
3 D04BAQ Drug Info IC50 = 13 nM [1]
4 D0G9OT Drug Info IC50 = 13 nM [1]
5 D0RK3S Drug Info IC50 = 14 nM [1]
Patent ID US0289506
Title 5-Membered Nitrogen Containing Heterocyclic Derivatives and Pharmaceutical Compositions Comprising The Same.
Applicant(s) Kissei Pharmaceutical Co. Ltd
Representative Drug(s) D0B5QZ Drug Info IC50 = 1.7 nM Click to Show More [1]
2 D0YX0S Drug Info IC50 = 3.3 nM [1]
3 D07TTT Drug Info IC50 = 5.2 nM [1]
4 D0QY4O Drug Info IC50 = 6.2 nM [1]
5 D0FM8Q Drug Info IC50 = 7.8 nM [1]
6 D0AU8E Drug Info IC50 = 52 nM [1]
Patent ID US0262567
Title Composition for Treating Gout, Containing Angelica Gigas Extract Having Xanthine Oxidase-Inhibiting Effect and An Inflammation Inducing Enzyme-Inhibiting Effect.
Applicant(s) Korea Bio Health Co. Ltd
Representative Drug(s) D04IGE Drug Info IC50 = 18000 ng/ml Click to Show More [1]
2 D0RN2X Drug Info IC50 = 18000 ng/ml [1]
Patent ID US0217878
Title (Aza)Indolizine Derivative and Pharmaceutical Use Thereof.
Applicant(s) Kissei Pharmaceutical Co. Ltd
Representative Drug(s) D0D6UT Drug Info IC50 = 3 nM Click to Show More [1]
2 D00GMJ Drug Info IC50 = 4 nM [1]
3 D0RK1R Drug Info IC50 = 4 nM [1]
4 D02VYR Drug Info IC50 = 5 nM [1]
5 D0J5GS Drug Info IC50 = 5 nM [1]
Patent ID US0201815
Title Fused Heterocyclic Derivative and Use Thereof for Medical Purposes.
Applicant(s) Kissei Pharmaceutical Co. Ltd
Representative Drug(s) D01FMW Drug Info IC50 = 5 nM Click to Show More [1]
2 D0AV1B Drug Info IC50 = 5 nM [1]
3 D03JDR Drug Info IC50 = 7 nM [1]
4 D0DQ6C Drug Info IC50 = 8 nM [1]
5 D0SY6J Drug Info IC50 = 8 nM [1]
6 D0NS7W Drug Info IC50 = 48 nM [1]
Patent ID US0189383
Title Use of Acacia Extracts and Their Compounds On Inhibition of Xanthine Oxidase.
Applicant(s) National Taiwan University
Representative Drug(s) D0J0JH Drug Info IC50 = 74 nM Click to Show More [1]
2 D0S0EM Drug Info IC50 = 270 nM [1]
Patent ID US8895626
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US8883858
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US8883857
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US0378552
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US0378478
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US0336204
Title Methods of Inhibiting Xanthine Oxidase Activity In A Cell.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US0329909
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US0281919
Title Agent for Treating or Preventing Digestive Ulcer.
Applicant(s) Astellas Pharma Inc
Representative Drug(s) D0GQ0V Drug Info IC50 < 1 nM [1]
Patent ID US005389
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US0004699
Title Small Molecule Xanthine Oxidase Inhibitor and Methods of Use.
Applicant(s) Baylor College of Medicine
Representative Drug(s) D0LX9F Drug Info IC50 = 3000 nM [1]
Patent ID US0165274
Title Xanthine Oxidase Inhibitor and Uric Acid Production Inhibitor.
Applicant(s) Kao Cororation
Canadian Intellectual Property Office (CIPO)
Patent ID CA2897928
Title Azole Benzene Derivative.
Applicant(s) Teizin Pharma Ltd
Representative Drug(s) D06XJG Drug Info IC50 < 5 nM Click to Show More [1]
2 D0J3ZM Drug Info IC50 < 5 nM [1]
3 D0VY5N Drug Info IC50 < 5 nM [1]
4 D0XY7C Drug Info IC50 < 5 nM [1]
Patent ID CA2859099
Title Terminalia Chebula and Terminalia Bellerica Extracts for Inhibition of Xanthine Oxidase.
Applicant(s) Natreon Inc
References  Top
REF 1 An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345.

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