| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO2012080762 |
| Title |
Novel Inhibitors of Matrix Metalloproteinases. |
| Abstract |
The present invention relates to compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)-R5; S(O)2-R6; R2 is H, aryl, heteroaryl, Y-(CH2)r-aryl, Y-(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive. |
| Applicant(s) |
Pharmahungary 2000 Kft |
| Representative Drug(s) |
D0X6GG |
Drug Info
|
IC50 = 2500 nM |
[1] |
| Patent ID |
WO2012038944 |
| Title |
Matrix Metalloproteinase Inhibitors. |
| Abstract |
The present invention relates to methyl sulfonamides and N-formamides derivatives of formula (I) and to processes for their syntheses. The invention also relates to pharmacological compositions containing these derivatives and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatie arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of an matrix metalloproteinase using the compounds. |
| Applicant(s) |
Ranbaxy Laboratories Limited |
| Representative Drug(s) |
D00ZZJ |
Drug Info
|
IC50 < 10000 nM |
[1] |
| Patent ID |
WO2012038943 |
| Title |
Matrix Metalloproteinase Inhibitors. |
| Abstract |
The present invention relates to certain sulfone acetic acid derivatives of formula I as MMP inhibitor and processes for its syntheses. The invention also relates to pharmacological compositions containing the compounds of the present invention and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple scleorisis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of a matrix metalloproteinase using the compounds. |
| Applicant(s) |
Ranbaxy Laboratories Limited |
| Representative Drug(s) |
D0LP0D |
Drug Info
|
IC50 < 10000 nM; IC50 > 10 nM |
[1] |
| Patent ID |
WO2012038942 |
| Title |
Matrix Metalloproteinase Inhibitors. |
| Abstract |
This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart faliure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of matrix metalloproteinase using the compounds. |
| Applicant(s) |
Ranbaxy Laboratories Limited |
| Representative Drug(s) |
D0L6HL |
Drug Info
|
IC50 > 130 nM; IC50 < 10000 nM |
[1] |
| Patent ID |
WO2012014114 |
| Title |
Matrix Metalloproteinase Inhibitors. |
| Abstract |
The present invention relates to certain hydroxy propionic acid derivatives and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over activation of a matrix metalloproteinase using the compounds. |
| Applicant(s) |
Ranbaxy Laboratories Limited |
| Representative Drug(s) |
D09ATD |
Drug Info
|
IC50 > 1000 nM; IC50 < 10000 nM |
[1] |
