Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T72881 Target Info
Target Name Leukotriene C4 synthase (LTC4S)
Synonyms Leukotriene-C(4)Leukotriene C4 synthase synthase; Leukotriene-C(4) synthase; LTC4 synthase
Target Type Patented-recorded Target
Gene Name LTC4S
Biochemical Class Carbon-sulfur lyase
UniProt ID
LTC4S_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9657001
Title Compounds and uses
Abstract There is provided compounds of formula I, wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.
Applicant(s) ASTRAZENECA AB
Representative Drug(s) D0V6RN Drug Info IC50 = 31 nM Click to Show More [1]
2 D08NHT Drug Info IC50 = 75 nM [1]
Patent ID US9657001
Title Compounds and uses
Abstract There is provided compounds of formula I, wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.
Applicant(s) ASTRAZENECA AB
Representative Drug(s) D0V6RN Drug Info IC50 = 31 nM Click to Show More [1]
2 D08NHT Drug Info IC50 = 75 nM [1]
Patent ID US20160326143
Title COMPOUNDS AND USES
Abstract There is provided compounds of formula I, wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.
Applicant(s) Astrazeneca Ab
Representative Drug(s) D0CT4T Drug Info IC50 = 67 nM Click to Show More [2]
2 D0L5VH Drug Info IC50 = 149 nM [2]
Patent ID US20160326143
Title COMPOUNDS AND USES
Abstract There is provided compounds of formula I, wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.
Applicant(s) Astrazeneca Ab
Representative Drug(s) D0CT4T Drug Info IC50 = 67 nM Click to Show More [2]
2 D0L5VH Drug Info IC50 = 149 nM [2]
References  Top
REF 1 Compounds and uses. US9657001.
REF 2 COMPOUNDS AND USES. US20160326143.

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