Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T80487 | Target Info | |||
| Target Name | DNA [cytosine-5]-methyltransferase 3-like (DNMT3L) | ||||
| Synonyms | DNA (cytosine-5)-methyltransferase 3-like | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | DNMT3L | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2013062945 | ||||
| Title | Chemical Compounds. | ||||
| Abstract | The invention is directed to substituted heteroaryl derivatives. Specifically, the invention is directed to compounds according to Formula Q: wherein D, L, M, W, X, Y, and Z are defined herein. The compounds of the invention are inhibitors of DNA methyltransferase (DNMT) activity - including DNMT1, DNMT3a, or DNMT3b - and are useful in the treatment of cancer and hyperproliferative diseases. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. | ||||
| Applicant(s) | Glaxosmithkline Intellectual Property (No.2) Limited | ||||
| Patent ID | WO2013062943 | ||||
| Title | New Compounds. | ||||
| Abstract | This invention relates to heteroaryl compounds, containing a purinyl moiety, that inhibit DNA methyltransferase (DNMT) activity - including DNMT1, DNMT3a, or DNMT3b - useful in the treatment of cancer and hyperproliferative diseases. | ||||
| Applicant(s) | Glaxosmithkline Intellectual Property (No.2) Limited | ||||
| Representative Drug(s) | D01LUJ | Drug Info | IC50 = 3000 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. | ||||
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