Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T95878 Target Info
Target Name Ribosomal protein S6 kinase alpha-6 (RSK6)
Synonyms pp90RSK4; p90RSK6; p90-RSK 6; S6K-alpha-6; Ribosomal S6 kinase 4; RSK4; RSK-4; 90 kDa ribosomal protein S6 kinase 6
Target Type Patented-recorded Target
Gene Name RPS6KA6
UniProt ID
KS6A6_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9771366
Title Substituted tetrahydropyrido[3,2:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors
Abstract Described herein are carboxamide derivatives of Formula (II) that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity: wherein R2, R4a, R4b, R11, R12, and n are defined in the specification.
Applicant(s) PHOENIX MOLECULAR DESIGN
Representative Drug(s) D0X7ZB Drug Info IC50 = 0.3 nM Click to Show More [1]
2 D0Z6IH Drug Info IC50 = 8 nM [1]
Patent ID US9771366
Title Substituted tetrahydropyrido[3,2:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors
Abstract Described herein are carboxamide derivatives of Formula (II) that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity: wherein R2, R4a, R4b, R11, R12, and n are defined in the specification.
Applicant(s) PHOENIX MOLECULAR DESIGN
Representative Drug(s) D0X7ZB Drug Info IC50 = 0.3 nM Click to Show More [1]
2 D0Z6IH Drug Info IC50 = 8 nM [1]
References  Top
REF 1 Substituted tetrahydropyrido[3,2:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors. US9771366.

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