Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Cyclic AMP-responsive element-binding protein (CREB1) | Literature-reported | Target Info | ||
| UniProt ID | CREB1_HUMAN | ||||
| Gene Name | CREB1 | ||||
| Gene ID | 1385 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [1] | |
| CREB-binding protein (CREBBP) | Target Info | PPI Info | [2] | ||
| Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [4] | ||
| Interacting Discontinued Target(s) | Transcription factor AP-1 (JUN) | Target Info | PPI Info | [3] | |
| Interacting Patented-recorded Target(s) | Ribosomal protein S6 kinase alpha-5 (RSK5) | Target Info | PPI Info | [5] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation. Biochem Biophys Res Commun. 2011 Mar 4;406(1):79-84. | ||||
| REF 2 | An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10;442(7103):700-4. | ||||
| REF 3 | Heterodimer formation between CREB and JUN proteins. Oncogene. 1990 Mar;5(3):295-302. | ||||
| REF 4 | The prostaglandin transporter regulates adipogenesis and aromatase transcription. Cancer Prev Res (Phila). 2011 Feb;4(2):194-206. | ||||
| REF 5 | Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41. | ||||
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