Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
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Target General Information  Top
Target ID T03634 Target Info
Target Name CREB-binding protein (CREBBP)
Synonyms CREBbinding protein; CBP
Target Type Clinical trial Target
Gene Name CREBBP
Biochemical Class Acyltransferase
UniProt ID
CBP_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name X-ray repair cross-complementing protein 6 (XRCC6) Interacting Protein Interacting Protein Info
UniProt ID
XRCC6_HUMAN 
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [1]
3 Reconstituted Complex [2]
4 Yeast two hybrid [2]
Acyltransferases [+] 6 Acyltransferases +
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Co-fractionation [3]
4 Reconstituted Complex [5]
5 Reconstituted Complex [4]
6 Reconstituted Complex [6]
7 Yeast two hybrid [6]
Interacting Protein Name Cyclic AMP-dependent transcription factor ATF-2 (ATF2) Interacting Protein Interacting Protein Info
UniProt ID
ATF2_HUMAN 
Synonyms CRE.BP1; CREB.2; CREB2; HB16; TREB7
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Reconstituted Complex [11]
6 Reconstituted Complex [8]
7 Yeast two hybrid [8]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [14]
4 Reconstituted Complex [12]
5 Reconstituted Complex [15]
6 Reconstituted Complex [16]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [17]
3 Reconstituted Complex [18]
4 Reconstituted Complex [19]
5 Reconstituted Complex [20]
6 Yeast two hybrid [19]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [22]
4 Reconstituted Complex [17]
5 Yeast two hybrid [17]
Interacting Protein Name SUMO-conjugating enzyme UBC9 (UBE2I) Interacting Protein Interacting Protein Info
UniProt ID
UBC9_HUMAN 
Synonyms C358B7.1; P18; UBC9
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [23]
2 Reconstituted Complex [24]
3 Yeast two hybrid [25]
Glycosylases [+] 1 Glycosylases +
Interacting Target Name Thymine-DNA glycosylase (TDG) Literature-reported Target Interacting Protein Info
UniProt ID
TDG_HUMAN 
Synonyms Thymine-DNA glycosylase; hTDG
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [26]
3 Biochemical Activity [5]
4 Co-fractionation [5]
5 Reconstituted Complex [5]
6 Reconstituted Complex [27]
7 Yeast two hybrid [5]
Kinases [+] 5 Kinases +
Interacting Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target Interacting Protein Info
UniProt ID
FGFR1_HUMAN 
Synonyms N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Affinity Capture-Western [29]
3 Co-localization [29]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Co-localization [30]
3 Reconstituted Complex [31]
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [32]
2 Far Western [33]
3 Reconstituted Complex [33]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [35]
3 Yeast two hybrid [34]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Co-localization [36]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Importin subunit alpha-1 (KPNA2) Interacting Protein Interacting Protein Info
UniProt ID
IMA1_HUMAN 
Synonyms IPOA1; QIP2; RCH1; SRP1alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Biochemical Activity [38]
Nuclear hormone receptors [+] 5 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [40]
4 Yeast two hybrid [39]
5 Yeast two hybrid [41]
Interacting Target Name Hepatocyte nuclear factor 4-alpha (HNF4A) Literature-reported Target Interacting Protein Info
UniProt ID
HNF4A_HUMAN 
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF-14; TCF14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF-4-alpha; HNF4
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Biochemical Activity [43]
3 Reconstituted Complex [44]
4 Reconstituted Complex [45]
5 Yeast two hybrid [44]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-peptide [46]
2 Reconstituted Complex [47]
3 Yeast two hybrid [48]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Reconstituted Complex [50]
3 Yeast two hybrid [51]
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Reconstituted Complex [53]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Target Name Mixed-lineage leukemia protein (MLL) Literature-reported Target Interacting Protein Info
UniProt ID
KMT2A_HUMAN 
Synonyms Zinc finger protein HRX; Trithorax-like protein; Trithoraxlike protein; p320; p180; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Myeloid/lymphoid or mixed-lineage leukemia; MLL1; MLL cleavage product C180; Lysine N-methyltransferase 2A; Lysine Nmethyltransferase 2A; HTRX; HRX; Histonelysine Nmethyltransferase MLL; Histone-lysine N-methyltransferase 2A; CXXC-type zinc finger protein 7; CXXCtype zinc finger protein 7; CXXC7; ALL-1; ALL1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Co-crystal Structure [55]
3 Co-crystal Structure [56]
4 Reconstituted Complex [55]
5 Reconstituted Complex [54]
6 Reconstituted Complex [57]
7 Yeast two hybrid [54]
Interacting Target Name Histone-arginine methyltransferase CARM1 (CARM1) Literature-reported Target Interacting Protein Info
UniProt ID
CARM1_HUMAN 
Synonyms Protein arginine N-methyltransferase 4; PRMT4; Histonearginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Coactivatorassociated arginine methyltransferase 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Biochemical Activity [59]
3 Reconstituted Complex [58]
4 Yeast two hybrid [58]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [60]
2 Affinity Capture-Western [35]
3 Affinity Capture-Western [61]
4 Affinity Capture-Western [62]
5 Biochemical Activity [63]
6 Biochemical Activity [64]
7 Biochemical Activity [24]
8 Biochemical Activity [65]
9 Biochemical Activity [66]
10 Biochemical Activity [67]
11 Biochemical Activity [68]
12 Biochemical Activity [69]
13 Co-crystal Structure [70]
14 Protein-peptide [71]
15 Reconstituted Complex [72]
16 Reconstituted Complex [73]
17 Reconstituted Complex [60]
18 Reconstituted Complex [18]
19 Reconstituted Complex [68]
20 Reconstituted Complex [74]
Transcription regulators [+] 33 Transcription regulators +
Interacting Target Name Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Interacting Protein Info
UniProt ID
CREB1_HUMAN 
Synonyms Cyclic AMP-responsive element-binding protein 1; Cyclic AMP responseelement-binding protein; CREB-1; CREB; cAMP-responsive element-binding protein 1; CAMP-response element binding protein
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [75]
2 Affinity Capture-Western [76]
3 Affinity Capture-Western [10]
4 Affinity Capture-Western [77]
5 Affinity Capture-Western [78]
6 Affinity Capture-Western [79]
7 Affinity Capture-Western [80]
8 Affinity Capture-Western [81]
9 Co-crystal Structure [56]
10 Co-crystal Structure [82]
11 Far Western [83]
12 Far Western [84]
13 Reconstituted Complex [83]
14 Reconstituted Complex [8]
15 Reconstituted Complex [73]
16 Reconstituted Complex [75]
17 Reconstituted Complex [78]
18 Reconstituted Complex [82]
19 Reconstituted Complex [85]
20 Reconstituted Complex [86]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-Western [87]
2 Affinity Capture-Western [34]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [88]
6 Affinity Capture-Western [89]
7 Affinity Capture-Western [90]
8 Affinity Capture-Western [91]
9 Affinity Capture-Western [92]
10 Affinity Capture-Western [93]
11 Affinity Capture-Western [94]
12 Reconstituted Complex [95]
13 Reconstituted Complex [11]
14 Reconstituted Complex [20]
15 Reconstituted Complex [91]
16 Reconstituted Complex [96]
17 Yeast two hybrid [91]
18 Yeast two hybrid [34]
Interacting Target Name Interferon regulatory factor 3 (IRF3) Literature-reported Target Interacting Protein Info
UniProt ID
IRF3_HUMAN 
Synonyms IRF-3
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-Western [97]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [98]
4 Affinity Capture-Western [99]
5 Affinity Capture-Western [88]
6 Affinity Capture-Western [100]
7 Affinity Capture-Western [101]
8 Affinity Capture-Western [102]
9 Affinity Capture-Western [103]
10 Affinity Capture-Western [104]
11 Affinity Capture-Western [105]
12 Affinity Capture-Western [106]
13 Affinity Capture-Western [107]
14 Reconstituted Complex [108]
Interacting Protein Name Transcriptional activator Myb (MYB) Interacting Protein Interacting Protein Info
UniProt ID
MYB_HUMAN 
Synonyms Transcriptional activator Myb; Proto-oncogene c-Myb
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [109]
2 Biochemical Activity [110]
3 Co-crystal Structure [111]
4 Co-crystal Structure [56]
5 Reconstituted Complex [111]
6 Reconstituted Complex [109]
7 Reconstituted Complex [110]
8 Reconstituted Complex [112]
9 Reconstituted Complex [113]
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [114]
2 Affinity Capture-Western [94]
3 Affinity Capture-Western [115]
4 Affinity Capture-Western [116]
5 Biochemical Activity [116]
6 Reconstituted Complex [117]
7 Reconstituted Complex [118]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [119]
2 Affinity Capture-Western [120]
3 Affinity Capture-Western [60]
4 Affinity Capture-Western [30]
5 Reconstituted Complex [121]
6 Reconstituted Complex [60]
Interacting Target Name Nuclear factor erythroid 2-related factor 2 (Nrf2) Successful Target Interacting Protein Info
UniProt ID
NF2L2_HUMAN 
Synonyms Nuclear factor, erythroid derived 2, like 2; NRF2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [89]
2 Affinity Capture-Western [122]
3 Biochemical Activity [122]
4 Reconstituted Complex [123]
5 Yeast two hybrid [123]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [124]
3 Far Western [84]
4 Reconstituted Complex [11]
5 Reconstituted Complex [8]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [125]
2 Affinity Capture-Western [126]
3 Affinity Capture-Western [127]
4 Affinity Capture-Western [128]
5 Yeast two hybrid [129]
Interacting Target Name Kruppel like factor 4 (KLF4) Clinical trial Target Interacting Protein Info
UniProt ID
KLF4_HUMAN 
Synonyms Krueppel-like factor 4; Krueppellike factor 4; Gut-enriched krueppel-like factor; Gutenriched krueppellike factor; GKLF; EZF; Epithelial zinc finger protein EZF
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [130]
2 Biochemical Activity [131]
3 Co-localization [132]
4 Reconstituted Complex [130]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [133]
2 Biochemical Activity [134]
3 Reconstituted Complex [134]
4 Yeast two hybrid [134]
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [135]
2 Affinity Capture-Western [136]
3 Biochemical Activity [135]
4 Reconstituted Complex [137]
Interacting Target Name Transcription factor E2-alpha (TCF3) Literature-reported Target Interacting Protein Info
UniProt ID
TFE2_HUMAN 
Synonyms Transcription factor ITF-1; Transcription factor 3; TCF-3; Kappa-E2-binding factor; ITF1; Immunoglobulin transcription factor 1; Immunoglobulin enhancer-binding factor E12/E47; E2A; Class B basic helix-loop-helix protein 21; bHLHb21
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [138]
2 Biochemical Activity [139]
3 Protein-peptide [139]
4 Reconstituted Complex [140]
Interacting Protein Name Homeobox protein Hox-B6 (HOXB6) Interacting Protein Interacting Protein Info
UniProt ID
HXB6_HUMAN 
Synonyms HOX2; HOX2B; HU.2; Hox.2.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [141]
2 Affinity Capture-Western [142]
3 Reconstituted Complex [141]
4 Reconstituted Complex [142]
Interacting Protein Name Myoblast determination protein 1 (MYOD1) Interacting Protein Interacting Protein Info
UniProt ID
MYOD1_HUMAN 
Synonyms MYF3; MYOD; PUM; bHLHc1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [143]
2 Biochemical Activity [144]
3 Biochemical Activity [64]
4 Reconstituted Complex [143]
Interacting Protein Name Autoimmune regulator (AIRE) Interacting Protein Interacting Protein Info
UniProt ID
AIRE_HUMAN 
Synonyms AIRE1; APECED; APS1; APSI; PGA1
Evidence Score (E-score) 4 Experimental Evidences +
1 Far Western [145]
2 Far Western [146]
3 Yeast two hybrid [145]
4 Yeast two hybrid [146]
Interacting Protein Name Homeobox protein Hox-B7 (HOXB7) Interacting Protein Interacting Protein Info
UniProt ID
HXB7_HUMAN 
Synonyms HHO.C1; HOX2; HOX2C; Hox.2.3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [142]
2 Reconstituted Complex [147]
3 Reconstituted Complex [142]
4 Yeast two hybrid [147]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [148]
2 Reconstituted Complex [149]
3 Reconstituted Complex [150]
4 Yeast two hybrid [149]
Interacting Protein Name Signal transducer and activator of transcription 2 (STAT2) Interacting Protein Interacting Protein Info
UniProt ID
STAT2_HUMAN 
Synonyms ISGF.3; P113; STAT113
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [151]
2 Reconstituted Complex [151]
3 Reconstituted Complex [152]
4 Yeast two hybrid [151]
Interacting Target Name Sterol regulatory element binding protein-1 (SREBF1) Literature-reported Target Interacting Protein Info
UniProt ID
SRBP1_HUMAN 
Synonyms Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding protein 1; SREBP-1; SREBP1; SREBP 1; Class D basic helix-loop-helix protein 1; bHLHd1
Evidence Score (E-score) 3 Experimental Evidences +
1 Far Western [153]
2 Reconstituted Complex [154]
3 Reconstituted Complex [56]
Interacting Protein Name Serum response factor (SRF) Interacting Protein Interacting Protein Info
UniProt ID
SRF_HUMAN 
Synonyms MCM1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [155]
2 Affinity Capture-Western [156]
3 Yeast two hybrid [156]
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [157]
2 Biochemical Activity [158]
Interacting Target Name Hepatocyte nuclear factor 1-alpha (HNF1A) Clinical trial Target Interacting Protein Info
UniProt ID
HNF1A_HUMAN 
Synonyms Transcription factor-1; Transcription factor 1; TCF-1; TCF1; Liver-specific transcription factor LF-B1; Liver specific transcription factor LF-B1; LFB1; HNF-1-alpha; HNF-1A; HNF-1 alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [159]
2 Reconstituted Complex [160]
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [161]
2 Yeast two hybrid [162]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [163]
2 Affinity Capture-Western [164]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [36]
2 Reconstituted Complex [165]
Interacting Target Name Protein C-ets-1 (ETS1) Literature-reported Target Interacting Protein Info
UniProt ID
ETS1_HUMAN 
Synonyms P54; EWSR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [124]
2 Reconstituted Complex [166]
Interacting Target Name Proto-oncogene c-Fos (c-Fos) Literature-reported Target Interacting Protein Info
UniProt ID
FOS_HUMAN 
Synonyms Proto-oncogene c-Fos; G0S7; G0/G1 switch regulatory protein 7; C-fos; Cellular oncogene fos
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [167]
2 Reconstituted Complex [40]
Interacting Target Name High mobility group protein HMG-I/Y (HMGA1) Literature-reported Target Interacting Protein Info
UniProt ID
HMGA1_HUMAN 
Synonyms HMGIY; HMG-I(Y); High mobility group protein R; High mobility group protein HMG-I/HMG-Y; High mobility group protein A1; High mobility group AT-hook protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [168]
2 Yeast two hybrid [169]
Interacting Protein Name Forkhead box protein O4 (FOXO4) Interacting Protein Interacting Protein Info
UniProt ID
FOXO4_HUMAN 
Synonyms AFX; AFX1; MLLT7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [170]
2 Reconstituted Complex [137]
Interacting Protein Name Hepatocyte nuclear factor 6 (ONECUT1) Interacting Protein Interacting Protein Info
UniProt ID
HNF6_HUMAN 
Synonyms HNF.6; HNF6; HNF6A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [171]
2 Reconstituted Complex [172]
Interacting Protein Name Myb-related protein A (MYBL1) Interacting Protein Interacting Protein Info
UniProt ID
MYBA_HUMAN 
Synonyms A.MYB; AMYB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [109]
2 Reconstituted Complex [173]
Interacting Protein Name Sterol regulatory element-binding protein 2 (SREBF2) Interacting Protein Interacting Protein Info
UniProt ID
SRBP2_HUMAN 
Synonyms SREBP.2; SREBP2; bHLHd2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [174]
2 Far Western [153]
Ubiquitin related proteins [+] 3 Ubiquitin related proteins +
Interacting Protein Name Anaphase-promoting complex subunit 7 (ANAPC7) Interacting Protein Interacting Protein Info
UniProt ID
APC7_HUMAN 
Synonyms APC7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [175]
2 Affinity Capture-Western [176]
3 Reconstituted Complex [175]
Interacting Protein Name Small ubiquitin-related modifier 1 (SUMO1) Interacting Protein Interacting Protein Info
UniProt ID
SUMO1_HUMAN 
Synonyms DAP1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; UBL1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [177]
2 Reconstituted Complex [177]
3 Reconstituted Complex [24]
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [178]
2 Biochemical Activity [179]
Other proteins [+] 4 Other proteins +
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [180]
2 Affinity Capture-Western [181]
3 Affinity Capture-Western [182]
4 Biochemical Activity [183]
5 Reconstituted Complex [180]
6 Yeast two hybrid [180]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [155]
2 Affinity Capture-Western [184]
3 Affinity Capture-Western [185]
4 Reconstituted Complex [184]
Interacting Target Name Huntingtin (HTT) Clinical trial Target Interacting Protein Info
UniProt ID
HD_HUMAN 
Synonyms IT15; Huntington disease protein; Huntingtin; HD protein; HD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [186]
2 Co-fractionation [187]
3 Reconstituted Complex [188]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [189]
2 Co-localization [190]
References  Top
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REF 131 Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem. 2007 Nov 23;282(47):33994-4002.
REF 132 Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors. Blood. 2011 Jun 9;117(23):6383-91.
REF 133 Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. Oncogene. 2007 Jan 18;26(3):382-94.
REF 134 Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep. 2003 May;4(5):484-90.
REF 135 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7.
REF 136 CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol Cancer Ther. 2014 Mar;13(3):687-98.
REF 137 DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10412-7.
REF 138 Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J Biol Chem. 2003 Jan 24;278(4):2370-6.
REF 139 Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation. Biochim Biophys Acta. 2012 May;1819(5):375-81.
REF 140 E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. J Biol Chem. 2004 Dec 31;279(53):55362-71.
REF 141 HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process. J Biol Chem. 2004 Sep 17;279(38):39895-904.
REF 142 The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol Cell Biol. 2001 Nov;21(21):7509-22.
REF 143 Interaction between acetylated MyoD and the bromodomain of CBP and/or p300. Mol Cell Biol. 2001 Aug;21(16):5312-20.
REF 144 CREB-binding protein/p300 activates MyoD by acetylation. J Biol Chem. 2000 Nov 3;275(44):34359-64.
REF 145 The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J Biol Chem. 2000 Jun 2;275(22):16802-9.
REF 146 P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain. J Bone Miner Res. 2003 Aug;18(8):1419-29.
REF 147 CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein. Oncogene. 1999 Jul 8;18(27):4007-14.
REF 148 MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol. 2005 Feb;25(3):988-1002.
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