Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | Cyclic AMP-dependent transcription factor ATF-2 (ATF2) | ||||
UniProt ID | ATF2_HUMAN | ||||
Gene Name | ATF2 | ||||
Gene ID | 1386 |
Interacting TTD Target Information | Top | ||||
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Interacting Clinical trial Target(s) | Stress-activated protein kinase 2a (p38 alpha) | Target Info | PPI Info | [1] | |
Stress-activated protein kinase JNK1 (JNK1) | Target Info | PPI Info | [2] | ||
CREB-binding protein (CREBBP) | Target Info | PPI Info | [3] | ||
Interacting Patented-recorded Target(s) | Stress-activated protein kinase JNK3 (JNK3) | Target Info | PPI Info | [4] | |
Interacting Preclinical Target(s) | Stress-activated protein kinase JNK2 (JNK2) | Target Info | PPI Info | [5] | |
Interacting Discontinued Target(s) | Transcription factor AP-1 (JUN) | Target Info | PPI Info | [6] | |
Interacting Literature-reported Target(s) | Proto-oncogene c-Fos (c-Fos) | Target Info | PPI Info | [7] | |
Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science. 1998 May 22;280(5367):1262-5. | ||||
REF 2 | c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors. J Biol Chem. 1997 Dec 19;272(51):32163-8. | ||||
REF 3 | A novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters I.3 and II by disrupting a transcriptional complex in br... J Biol Chem. 2006 Feb 3;281(5):2585-97. | ||||
REF 4 | IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Mol Cell Biol. 2002 Mar;22(6):1754-66. | ||||
REF 5 | A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003 Aug 29;278(35):32662-72. | ||||
REF 6 | Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene. J Leukoc Biol. 1994 Jul;56(1):27-35. | ||||
REF 7 | Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4. |
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