Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T00663 Target Info
Target Name Stress-activated protein kinase JNK3 (JNK3)
Synonyms Stress-activated protein kinase 1b; SAPK1b; PRKM10; Mitogen-activated protein kinase 10; MAPK 10; MAP kinase p49 3F12; MAP kinase 10; JNK3A; C-Jun N-terminal kinase 3
Target Type Patented-recorded Target
Gene Name MAPK10
Biochemical Class Kinase
UniProt ID
MK10_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Cyclic AMP-dependent transcription factor ATF-2 (ATF2) Interacting Protein Interacting Protein Info
UniProt ID
ATF2_HUMAN 
Synonyms CRE.BP1; CREB.2; CREB2; HB16; TREB7
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [1]
2 Biochemical Activity [2]
3 Reconstituted Complex [2]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 6 Experimental Evidences +
1 Biochemical Activity [3]
2 Biochemical Activity [2]
3 Biochemical Activity [4]
4 Biochemical Activity [5]
5 Biochemical Activity [6]
6 Reconstituted Complex [2]
Other proteins [+] 3 Other proteins +
Interacting Protein Name C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3) Interacting Protein Interacting Protein Info
UniProt ID
JIP3_HUMAN 
Synonyms JIP3; JSAP1; SYD2; syd
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [7]
2 Biochemical Activity [8]
3 Yeast two hybrid [7]
Interacting Target Name Beta-arrestin-1 (ARRB1) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB1_HUMAN 
Synonyms Non-visual arrestin-2; Betaarrestin1; Arrestin beta-1; Arrestin beta1; ARR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Protein-peptide [10]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Protein-peptide [10]
References  Top
REF 1 IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Mol Cell Biol. 2002 Mar;22(6):1754-66.
REF 2 Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996 Jun 3;15(11):2760-70.
REF 3 Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science. 1998 May 22;280(5367):1262-5.
REF 4 A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett. 2009 Jul 7;583(13):2208-12.
REF 5 c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis. J Dermatol Sci. 2006 Sep;43(3):171-9.
REF 6 The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity. Nat Struct Mol Biol. 2005 Aug;12(8):699-707.
REF 7 JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. Mol Cell Biol. 1999 Nov;19(11):7539-48.
REF 8 Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. J Biol Chem. 2002 Oct 25;277(43):40703-9.
REF 9 Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. J Biol Chem. 2001 Jul 27;276(30):27770-7.
REF 10 A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. FEBS Lett. 2009 Oct 20;583(20):3310-6.

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