Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T69375 Target Info
Target Name Stress-activated protein kinase JNK2 (JNK2)
Synonyms Stress-activated protein kinase 1a; SAPK1a; PRKM9; Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 8-interacting protein 2; MAPK 9; MAP kinase 9; Jun-N-terminal kinase 2; JNK-interacting protein 2; JNK-55; JNK MAP kinase scaffold protein 2; JIP-2; Islet-brain-2; IB-2; C-jun-amino-terminal kinase interacting protein 2; C-Jun N-terminal kinase 2
Target Type Preclinical Target
Gene Name MAPK9
Biochemical Class Kinase
UniProt ID
MK09_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Cyclic AMP-dependent transcription factor ATF-2 (ATF2) Interacting Protein Interacting Protein Info
UniProt ID
ATF2_HUMAN 
Synonyms CRE.BP1; CREB.2; CREB2; HB16; TREB7
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Dual specificity protein phosphatase 10 (DUSP10) Literature-reported Target Interacting Protein Info
UniProt ID
DUS10_HUMAN 
Synonyms MKP-5; MKP5; Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [6]
2 Yeast two hybrid [7]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [8]
2 Reconstituted Complex [2]
3 Yeast two hybrid [3]
Interacting Protein Name ETS domain-containing protein Elk-1 (ELK1) Interacting Protein Interacting Protein Info
UniProt ID
ELK1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [2]
2 Yeast two hybrid [3]
Other proteins [+] 2 Other proteins +
Interacting Target Name JNK-interacting protein 1 peptide (pepJIP1) Patented-recorded Target Interacting Protein Info
UniProt ID
JIP1_HUMAN 
Synonyms PRKM8IP; Mitogen-activated protein kinase 8-interacting protein 1; JNK-interacting protein 1; JNK MAP kinase scaffold protein 1; JIP-1; JIP1; Islet-brain 1; IB-1; IB1; C-Jun-amino-terminal kinase-interacting protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [9]
Interacting Protein Name WD repeat-containing protein 62 (WDR62) Interacting Protein Interacting Protein Info
UniProt ID
WDR62_HUMAN 
Synonyms C19orf14; MCPH2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Yeast two hybrid [11]
References  Top
REF 1 A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003 Aug 29;278(35):32662-72.
REF 2 Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996 Jun 3;15(11):2760-70.
REF 3 Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation. Cancer Res. 2007 Sep 15;67(18):8725-35.
REF 4 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 5 A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J Biol Chem. 2001 Jul 13;276(28):26629-39.
REF 6 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 7 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 8 c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 1996 Nov 29;87(5):929-39.
REF 9 The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999 Oct;19(10):7245-54.
REF 10 A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation. Mol Biol Cell. 2010 Jan 1;21(1):117-30.
REF 11 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.

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