Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | JNK-interacting protein 1 peptide (pepJIP1) | Patented-recorded | Target Info | ||
| UniProt ID | JIP1_HUMAN | ||||
| Gene Name | MAPK8IP1 | ||||
| Gene ID | 9479 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Amyloid beta A4 protein (APP) | Target Info | PPI Info | [1] | |
| RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | Stress-activated protein kinase JNK1 (JNK1) | Target Info | PPI Info | [3] | |
| Interacting Preclinical Target(s) | Stress-activated protein kinase JNK2 (JNK2) | Target Info | PPI Info | [4] | |
| Interacting Literature-reported Target(s) | Mixed lineage kinase 3 (MAP3K11) | Target Info | PPI Info | [4] | |
| ERK activator kinase 7 (MAP2K7) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol. 2005 Nov 21;171(4):615-25. | ||||
| REF 2 | Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 2002 Aug 15;35(4):697-709. | ||||
| REF 3 | Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. J Cell Biol. 2005 Jul 4;170(1):61-72. | ||||
| REF 4 | The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999 Oct;19(10):7245-54. | ||||
| REF 5 | Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. J Virol. 2006 Aug;80(15):7667-75. | ||||
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