Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T87024 Target Info
Target Name Amyloid beta A4 protein (APP)
Synonyms Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
Target Type Successful Target
Gene Name APP
Biochemical Class Amyloid beta-protein peptide
UniProt ID
A4_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Histone acetyltransferase KAT5 (KAT5) Interacting Protein Interacting Protein Info
UniProt ID
KAT5_HUMAN 
Synonyms ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5; cPLA2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Fluorescence Resonance Energy Transfer [2]
3 Fluorescence Resonance Energy Transfer [1]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Amyloid-beta A4 precursor protein-binding family B member 1 (APBB1) Interacting Protein Interacting Protein Info
UniProt ID
APBB1_HUMAN 
Synonyms FE65; MGC:9072; RIR
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [4]
4 Protein-Fragment Complementation Assay [5]
5 Reconstituted Complex [6]
6 Yeast two hybrid [7]
7 Yeast two hybrid [4]
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Protein Name Amyloid-beta A4 precursor protein-binding family A member 1 (APBA1) Interacting Protein Interacting Protein Info
UniProt ID
APBA1_HUMAN 
Synonyms D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [8]
3 Reconstituted Complex [6]
Interacting Protein Name Amyloid-beta A4 precursor protein-binding family A member 2 (APBA2) Interacting Protein Interacting Protein Info
UniProt ID
APBA2_HUMAN 
Synonyms D15S1518E; HsT16821; LIN.10; MGC:14091; MINT2; X11.BETA; X11L
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [8]
Growth factors [+] 1 Growth factors +
Interacting Target Name Transforming growth factor beta 1 (TGFB1) Successful Target Interacting Protein Info
UniProt ID
TGFB1_HUMAN 
Synonyms Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1; TGF-beta1; TGF-beta 1; TGFB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Co-localization [11]
Isomerases [+] 1 Isomerases +
Interacting Target Name Mitochondrial matrix protein P1 (HSPD1) Clinical trial Target Interacting Protein Info
UniProt ID
CH60_HUMAN 
Synonyms P60 lymphocyte protein; HuCHA60; HSP-60; Hsp60; Heat shock protein 60; CPN60; Chaperonin 60; 60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
Kinases [+] 3 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [14]
2 Yeast two hybrid [15]
Interacting Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Interacting Protein Info
UniProt ID
GSK3B_HUMAN 
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [13]
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [17]
2 Reconstituted Complex [13]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [13]
Other proteins [+] 6 Other proteins +
Interacting Target Name JNK-interacting protein 1 peptide (pepJIP1) Patented-recorded Target Interacting Protein Info
UniProt ID
JIP1_HUMAN 
Synonyms PRKM8IP; Mitogen-activated protein kinase 8-interacting protein 1; JNK-interacting protein 1; JNK MAP kinase scaffold protein 1; JIP-1; JIP1; Islet-brain 1; IB-1; IB1; C-Jun-amino-terminal kinase-interacting protein 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [17]
3 Reconstituted Complex [17]
4 Yeast two hybrid [5]
Interacting Target Name Clusterin (CLU) Literature-reported Target Interacting Protein Info
UniProt ID
CLUS_HUMAN 
Synonyms TRPM-2; Testosterone-repressed prostate message 2; Testosteronerepressed prostate message 2; NA1/NA2; KUB1; Ku70-binding protein 1; Ku70binding protein 1; Complement-associated protein SP-40,40; Complementassociated protein SP40,40; Complement cytolysis inhibitor; Clusterin alpha chain; Clusterin; CLI; Apolipoprotein J; Apo-J; ApoJ; Aging-associated gene 4 protein; Agingassociated gene 4 protein; AAG4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Fluorescence Resonance Energy Transfer [20]
3 Reconstituted Complex [21]
4 Reconstituted Complex [22]
Interacting Protein Name Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3) Interacting Protein Interacting Protein Info
UniProt ID
APBA3_HUMAN 
Synonyms MGC:15815; X11L2; mint3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [8]
3 Reconstituted Complex [23]
4 Yeast two hybrid [23]
Interacting Target Name Synuclein alpha (SNCA) Clinical trial Target Interacting Protein Info
UniProt ID
SYUA_HUMAN 
Synonyms PARK1; Non-A4 component of amyloid precursor; NonA4 component of amyloid precursor; Non-A beta component of AD amyloid; NonA beta component of AD amyloid; NACP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Co-localization [11]
3 Reconstituted Complex [25]
Interacting Protein Name Alzheimer disease amyloid-associated protein (COL25A1) Interacting Protein Interacting Protein Info
UniProt ID
COPA1_HUMAN 
Synonyms AMY; CLAC; CLAC.P; CLACP
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [26]
2 Reconstituted Complex [27]
Interacting Protein Name Zinc finger CCCH domain-containing protein 3 (ZC3H3) Interacting Protein Interacting Protein Info
UniProt ID
ZC3H3_HUMAN 
Synonyms ZC3HDC3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Reconstituted Complex [29]
References  Top
REF 1 The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci. 2004 Sep 1;117(Pt 19):4435-48.
REF 2 The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem. 2002 Aug 9;277(32):28530-6.
REF 3 Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction. Biochim Biophys Acta. 2007 Jun;1773(6):736-46.
REF 4 Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem. 2004 Jun 4;279(23):24601-11.
REF 5 Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Mol Neurodegener. 2010 Jan 14;5:1.
REF 6 The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol Cell Biol. 1996 Nov;16(11):6229-41.
REF 7 Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem. 1998 Dec 11;273(50):33556-60.
REF 8 Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. J Neurosci. 2002 Sep 1;22(17):7340-51.
REF 9 Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem. 2003 Dec 5;278(49):49448-58.
REF 10 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 11 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 12 CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Hum Mol Genet. 2007 Apr 1;16(7):848-64.
REF 13 Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. J Biol Chem. 2011 Sep 30;286(39):34088-100.
REF 14 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 15 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 16 The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth. Biochim Biophys Acta. 2012 Aug;1823(8):1233-41.
REF 17 Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1. J Biol Chem. 2003 Oct 24;278(43):42058-63.
REF 18 COPS5 (Jab1) protein increases site processing of amyloid precursor protein and amyloid peptide generation by stabilizing RanBP9 protein levels. J Biol Chem. 2013 Sep 13;288(37):26668-77.
REF 19 Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol. 2005 Nov 21;171(4):615-25.
REF 20 Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease. PLoS One. 2013 Jun 21;8(6):e66384.
REF 21 Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J Biol Chem. 1997 Jul 25;272(30):18644-9.
REF 22 The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. Biochem J. 1993 Jul 1;293 ( Pt 1):27-30.
REF 23 X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein. Biochem Biophys Res Commun. 1999 Feb 24;255(3):663-7.
REF 24 Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 4;3(9):e3135.
REF 25 Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC. Biochem J. 1997 Apr 15;323 ( Pt 2):539-46.
REF 26 Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site. J Biol Chem. 2005 Jan 14;280(2):1007-15.
REF 27 CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J. 2002 Apr 2;21(7):1524-34.
REF 28 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 29 Protein array based interactome analysis of amyloid- indicates an inhibition of protein translation. J Proteome Res. 2011 Apr 1;10(4):1538-47.

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