| References |
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Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science. 1998 May 22;280(5367):1262-5.
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| REF 2 |
Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression. Oncogene. 2008 Nov 6;27(52):6635-45.
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| REF 3 |
Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Mol Cell Biol. 2011 Jun;31(11):2349-63.
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| REF 4 |
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J Biol Chem. 2001 May 11;276(19):16070-5.
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Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem. 1997 May 30;272(22):14489-96.
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DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. J Cell Biochem. 2010 May;110(1):229-37.
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CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation. Mol Cell Biochem. 2014 Dec;397(1-2):139-46.
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The p38 pathway provides negative feedback for Ras proliferative signaling. J Biol Chem. 2000 Dec 15;275(50):38973-80.
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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem. 1995 Mar 31;270(13):7420-6.
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P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription. EMBO J. 2006 Feb 22;25(4):739-51.
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p62 functions as a p38 MAP kinase regulator. Biochem Biophys Res Commun. 2000 Mar 16;269(2):521-5.
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Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem. 2002 Apr 26;277(17):14408-16.
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p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem. 1997 Aug 1;272(31):19509-17.
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AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem. 2003 Jun 27;278(26):23432-40.
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MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. Cell Signal. 2003 Nov;15(11):993-1001.
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Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA. J Biol Chem. 2007 Feb 9;282(6):3766-77.
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| REF 17 |
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28;210(7):1117-31.
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Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest. 2006 Oct;116(10):2727-38.
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The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding. Biochemistry. 1998 Sep 29;37(39):13846-53.
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| REF 20 |
Tighter C-helix-L16-helix interactions seem to make p38 less prone to activation by autophosphorylation than Hog1. Biosci Rep. 2016 Apr 27;36(2). pii: e00324.
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MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol. 2007 Nov 15;179(10):7101-9.
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| REF 22 |
Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1. J Biochem. 2008 Jun;143(6):765-72.
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Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
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A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J Biol Chem. 2001 Jul 13;276(28):26629-39.
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Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J Biol Chem. 2001 May 11;276(19):16491-500.
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Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
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Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
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Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. EMBO J. 2001 Feb 1;20(3):466-79.
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The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
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Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
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A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
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Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
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p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem. 2001 Feb 2;276(5):3517-23.
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Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation. Biochem Biophys Res Commun. 1999 Dec 9;266(1):284-9.
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Molecular basis of MAPK-activated protein kinase 2:p38 assembly. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6353-8.
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Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation. Biochem J. 2011 Sep 15;438(3):495-503.
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Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
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MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood. 2004 Dec 15;104(13):4260-8.
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| REF 41 |
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). J Biol Chem. 1998 Nov 6;273(45):29661-71.
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| REF 42 |
Mxi2 promotes stimulus-independent ERK nuclear translocation. EMBO J. 2007 Feb 7;26(3):635-46.
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OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
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Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation. Exp Hematol. 2006 Oct;34(10):1360-76.
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| REF 45 |
p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels. Mol Cell Biol. 2003 May;23(9):3079-90.
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| REF 46 |
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. J Biol Chem. 2008 Sep 5;283(36):24949-61.
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| REF 47 |
A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
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TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner. Cell Cycle. 2006 Dec;5(23):2787-95.
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| REF 49 |
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 1999 Dec 1;18(23):6845-54.
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| REF 50 |
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope. J Exp Med. 2005 Jan 17;201(2):279-89.
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| REF 51 |
TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem. 2003 Jan 24;278(4):2286-93.
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| REF 52 |
Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP. EMBO J. 2010 Jan 6;29(1):27-40.
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| REF 53 |
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteomics. 2010 Jul;9(7):1578-93.
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| REF 54 |
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. EMBO J. 2007 Apr 18;26(8):2115-26.
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| REF 55 |
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res. 2008 Sep;7(9):3879-89.
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