Protein-Protein Interaction Details
Protein General Information | Top | ||||
---|---|---|---|---|---|
Full Name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) | ||||
UniProt ID | TAB1_HUMAN | ||||
Gene Name | TAB1 | ||||
Gene ID | 10454 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Tumor necrosis factor (TNF) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | Stress-activated protein kinase 2a (p38 alpha) | Target Info | PPI Info | [3] | |
X-linked inhibitor of apoptosis protein (XIAP) | Target Info | PPI Info | [4] | ||
Interacting Literature-reported Target(s) | TGF-beta-activated kinase 1 (MAP3K7) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44. | ||||
REF 3 | Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28;210(7):1117-31. | ||||
REF 4 | XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999 Jan 4;18(1):179-87. | ||||
REF 5 | TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996 May 24;272(5265):1179-82. |
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