Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T16769 | Target Info | |||
Target Name | X-linked inhibitor of apoptosis protein (XIAP) | ||||
Synonyms | hILP; hIAP3; hIAP-3; Xlinked IAP; X-linked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAPlike protein; IAP3; IAP-like protein; IAP-3; E3 ubiquitinprotein ligase XIAP; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeatcontaining protein 4; Baculoviral IAP repeat-containing protein 4; BIRC4; API3 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | XIAP | ||||
Biochemical Class | Acyltransferase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acid anhydride hydrolases | [+] 1 Acid anhydride hydrolases | + | |||
Interacting Target Name | Ras-related C3 botulinum toxin substrate 1 (RAC1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TC25; Ras-like protein TC25; p21-Rac1; MIG5; Cell migration-inducing gene5 protein; Cell migration-inducing gene 5 protein | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [1] | |||
2 | Affinity Capture-Western | [2] | |||
Acyltransferases | [+] 3 Acyltransferases | + | |||
Interacting Target Name | Cellular inhibitor of apoptosis 1 (BIRC2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-Western | [4] | |||
Interacting Target Name | Melanoma inhibitor of apoptosis protein (ML-IAP) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-Western | [5] | |||
Interacting Target Name | TNF receptor-associated factor 6 (TRAF6) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Co-localization | [6] | |||
2 | Yeast two hybrid | [7] | |||
Beta-transducin repeats | [+] 1 Beta-transducin repeats | + | |||
Interacting Protein Name | Transducin-like enhancer protein 3 (TLE3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ESG; ESG3; GRG3; HsT18976 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [8] | |||
2 | Biochemical Activity | [8] | |||
Kinases | [+] 5 Kinases | + | |||
Interacting Target Name | Proto-oncogene c-RAF (c-RAF) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [9] | |||
2 | Biochemical Activity | [9] | |||
3 | Co-localization | [6] | |||
4 | Reconstituted Complex | [9] | |||
5 | Yeast two hybrid | [9] | |||
Interacting Protein Name | Receptor-interacting protein 2 (RIP2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | UNQ277/PRO314/PRO34092; Tyrosine-protein kinase RIPK2; RIP-like-interacting CLARP kinase; RIP-2; RIP2; RICK; Receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting protein 2; CARDIAK; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [10] | |||
2 | Biochemical Activity | [11] | |||
3 | Reconstituted Complex | [12] | |||
4 | Yeast two hybrid | [13] | |||
Interacting Target Name | RAC-alpha serine/threonine-protein kinase (AKT1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [14] | |||
2 | Biochemical Activity | [15] | |||
3 | Co-localization | [6] | |||
Interacting Target Name | MAPK/ERK kinase kinase 2 (MAP3K2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2; MEK kinase 2; MAPKKK2 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [16] | |||
2 | Biochemical Activity | [16] | |||
3 | Reconstituted Complex | [17] | |||
Interacting Target Name | Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Serine/threonine-protein kinase GSK3B; GSK-3 beta | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [18] | |||
2 | Biochemical Activity | [19] | |||
Oxidoreductases | [+] 1 Oxidoreductases | + | |||
Interacting Protein Name | Programmed cell death protein 8 (AIFM1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AIF; CMT2D; CMTX4; COWCK; COXPD6; NADMR; NAMSD; PDCD8 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [20] | |||
2 | Biochemical Activity | [21] | |||
Peptidases | [+] 5 Peptidases | + | |||
Interacting Target Name | Caspase-9 (CASP9) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3 | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [22] | |||
2 | Biochemical Activity | [23] | |||
3 | Co-crystal Structure | [24] | |||
4 | Co-localization | [6] | |||
5 | Far Western | [25] | |||
6 | Reconstituted Complex | [26] | |||
7 | Yeast two hybrid | [27] | |||
Interacting Target Name | Caspase-3 (CASP3) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-Western | [28] | |||
3 | Biochemical Activity | [29] | |||
4 | Co-crystal Structure | [30] | |||
5 | Co-localization | [6] | |||
6 | Reconstituted Complex | [31] | |||
Interacting Target Name | Caspase-7 (CASP7) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [32] | |||
2 | Co-crystal Structure | [33] | |||
3 | Reconstituted Complex | [31] | |||
Interacting Protein Name | High temperature requirement protein A2 (HTRA2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | OMI; PARK13; PRSS25 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [34] | |||
2 | Affinity Capture-Western | [34] | |||
3 | Reconstituted Complex | [35] | |||
Interacting Target Name | Caspase-10 (CASP10) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MCH4; ICE-like apoptotic protease 4; FLICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP-10; Apoptotic protease Mch-4 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [36] | |||
2 | Yeast two hybrid | [13] | |||
Ubiquitin related proteins | [+] 6 Ubiquitin related proteins | + | |||
Interacting Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [37] | |||
2 | Protein-peptide | [38] | |||
3 | Reconstituted Complex | [39] | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [40] | |||
2 | Reconstituted Complex | [23] | |||
3 | Yeast two hybrid | [41] | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [40] | |||
2 | Reconstituted Complex | [42] | |||
3 | Yeast two hybrid | [41] | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E2(17)KB3; UBC4/5; UBCH5C | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [40] | |||
2 | Reconstituted Complex | [43] | |||
3 | Yeast two hybrid | [41] | |||
Interacting Target Name | Polyubiquitin-C (UBC) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HMG20; ubiquitin C | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Co-crystal Structure | [44] | |||
2 | Reconstituted Complex | [45] | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 E1 (UBE2E1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | UBCH6 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Reconstituted Complex | [46] | |||
2 | Yeast two hybrid | [41] | |||
Other proteins | [+] 5 Other proteins | + | |||
Interacting Target Name | Direct IAP-binding protein with low pI (DIABLO) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [47] | |||
2 | Affinity Capture-Western | [47] | |||
3 | Biochemical Activity | [48] | |||
4 | Co-crystal Structure | [49] | |||
5 | Far Western | [50] | |||
6 | Protein-peptide | [51] | |||
7 | Reconstituted Complex | [49] | |||
Interacting Protein Name | XIAP-associated factor 1 (XAF1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BIRC4BP; HSXIAPAF1; XIAPAF1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [52] | |||
2 | Biochemical Activity | [53] | |||
3 | Co-localization | [52] | |||
4 | Yeast two hybrid | [52] | |||
Interacting Target Name | Apoptosis inhibitor survivin (BIRC5) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [54] | |||
2 | Reconstituted Complex | [55] | |||
Interacting Protein Name | Apoptosis regulatory protein Siva (SIVA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CD27BP; SIVA; Siva.1; Siva.2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [56] | |||
2 | Yeast two hybrid | [56] | |||
Interacting Protein Name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | 3.Tab1; MAP3K7IP1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [57] | |||
2 | Yeast two hybrid | [57] |
References | Top | ||||
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REF 1 | AMPylation of Rho GTPases subverts multiple host signaling processes. J Biol Chem. 2014 Nov 21;289(47):32977-88. | ||||
REF 2 | IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012 Jan 4;31(1):14-28. | ||||
REF 3 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 4 | Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16182-7. | ||||
REF 5 | Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem. 2012 Aug 17;287(34):28445-55. | ||||
REF 6 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
REF 7 | Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Mol Cell Proteomics. 2012 Jul;11(7):M111.016162. | ||||
REF 8 | XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol Cell. 2012 Mar 9;45(5):619-28. | ||||
REF 9 | Interaction and stabilization of X-linked inhibitor of apoptosis by Raf-1 protein kinase. Int J Oncol. 2006 Oct;29(4):861-7. | ||||
REF 10 | Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37(17). pii: e99372. | ||||
REF 11 | Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med. 2013 Aug;5(8):1278-95. | ||||
REF 12 | cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356. | ||||
REF 13 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
REF 14 | Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis. 2013 Sep;34(9):2061-70. | ||||
REF 15 | Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem. 2004 Feb 13;279(7):5405-12. | ||||
REF 16 | XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. Cell Signal. 2008 Nov;20(11):2107-12. | ||||
REF 17 | Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801. | ||||
REF 18 | XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3. Cell Signal. 2009 Dec;21(12):1857-65. | ||||
REF 19 | Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. J Cell Sci. 2018 May 22;131(10). pii: jcs210575. | ||||
REF 20 | Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. Mol Cell Biol. 2008 Jan;28(1):237-47. | ||||
REF 21 | Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. Biochemistry. 2011 Dec 27;50(51):11084-96. | ||||
REF 22 | IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23. | ||||
REF 23 | X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem. 2005 Feb;137(2):125-32. | ||||
REF 24 | Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell. 2003 Feb;11(2):519-27. | ||||
REF 25 | Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J Biol Chem. 2004 Sep 24;279(39):40622-8. | ||||
REF 26 | IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81. | ||||
REF 27 | Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8. | ||||
REF 28 | Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol Cell. 2004 Jun 18;14(6):801-11. | ||||
REF 29 | Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12815-9. | ||||
REF 30 | XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J. 2005 Feb 9;24(3):645-55. | ||||
REF 31 | X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997 Jul 17;388(6639):300-4. | ||||
REF 32 | IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol. 2005 Jan;7(1):70-7. | ||||
REF 33 | Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell. 2001 Mar 9;104(5):781-90. | ||||
REF 34 | A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell. 2001 Sep;8(3):613-21. | ||||
REF 35 | The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ. 2002 Jan;9(1):20-6. | ||||
REF 36 | Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6170-5. | ||||
REF 37 | XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J. 2013 Aug 14;32(16):2204-16. | ||||
REF 38 | Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. Mol Cancer. 2015 Mar 26;14:65. | ||||
REF 39 | Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell. 2009 May 5;15(5):363-75. | ||||
REF 40 | Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60. | ||||
REF 41 | c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209. | ||||
REF 42 | Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase. Biochem J. 2013 Mar 15;450(3):629-38. | ||||
REF 43 | X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein. Int J Biochem Cell Biol. 2012 Mar;44(3):489-95. | ||||
REF 44 | Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association. PLoS One. 2011;6(12):e28511. | ||||
REF 45 | IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17. | ||||
REF 46 | Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res. 2009 Oct;19(10):1905-11. | ||||
REF 47 | Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000 Jul 7;102(1):43-53. | ||||
REF 48 | Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol. 2004 Sep;6(9):849-60. | ||||
REF 49 | Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 2000 Dec 21-28;408(6815):1004-8. | ||||
REF 50 | Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. J Biol Chem. 2003 Dec 26;278(52):52660-72. | ||||
REF 51 | The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):58-66. | ||||
REF 52 | Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. Nat Cell Biol. 2001 Feb;3(2):128-33. | ||||
REF 53 | Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1. Protein Sci. 2012 Oct;21(10):1418-28. | ||||
REF 54 | Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. J Biol Chem. 2007 Sep 7;282(36):26202-9. | ||||
REF 55 | An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13;279(33):34087-90. | ||||
REF 56 | Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis. J Cell Sci. 2009 Aug 1;122(Pt 15):2651-61. | ||||
REF 57 | XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999 Jan 4;18(1):179-87. |
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