| References |
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| REF 1 |
AMPylation of Rho GTPases subverts multiple host signaling processes. J Biol Chem. 2014 Nov 21;289(47):32977-88.
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| REF 2 |
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012 Jan 4;31(1):14-28.
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| REF 3 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 4 |
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16182-7.
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| REF 5 |
Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem. 2012 Aug 17;287(34):28445-55.
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| REF 6 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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| REF 7 |
Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Mol Cell Proteomics. 2012 Jul;11(7):M111.016162.
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| REF 8 |
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol Cell. 2012 Mar 9;45(5):619-28.
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| REF 9 |
Interaction and stabilization of X-linked inhibitor of apoptosis by Raf-1 protein kinase. Int J Oncol. 2006 Oct;29(4):861-7.
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| REF 10 |
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37(17). pii: e99372.
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| REF 11 |
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med. 2013 Aug;5(8):1278-95.
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| REF 12 |
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356.
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| REF 13 |
A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
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| REF 14 |
Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis. 2013 Sep;34(9):2061-70.
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| REF 15 |
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem. 2004 Feb 13;279(7):5405-12.
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| REF 16 |
XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. Cell Signal. 2008 Nov;20(11):2107-12.
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| REF 17 |
Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
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| REF 18 |
XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3. Cell Signal. 2009 Dec;21(12):1857-65.
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| REF 19 |
Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. J Cell Sci. 2018 May 22;131(10). pii: jcs210575.
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| REF 20 |
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. Mol Cell Biol. 2008 Jan;28(1):237-47.
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| REF 21 |
Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. Biochemistry. 2011 Dec 27;50(51):11084-96.
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| REF 22 |
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23.
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| REF 23 |
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem. 2005 Feb;137(2):125-32.
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| REF 24 |
Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell. 2003 Feb;11(2):519-27.
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| REF 25 |
Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J Biol Chem. 2004 Sep 24;279(39):40622-8.
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| REF 26 |
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81.
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| REF 27 |
Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
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| REF 28 |
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol Cell. 2004 Jun 18;14(6):801-11.
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| REF 29 |
Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12815-9.
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| REF 30 |
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J. 2005 Feb 9;24(3):645-55.
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| REF 31 |
X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997 Jul 17;388(6639):300-4.
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| REF 32 |
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol. 2005 Jan;7(1):70-7.
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| REF 33 |
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell. 2001 Mar 9;104(5):781-90.
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| REF 34 |
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell. 2001 Sep;8(3):613-21.
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| REF 35 |
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ. 2002 Jan;9(1):20-6.
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| REF 36 |
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6170-5.
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| REF 37 |
XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J. 2013 Aug 14;32(16):2204-16.
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| REF 38 |
Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. Mol Cancer. 2015 Mar 26;14:65.
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| REF 39 |
Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell. 2009 May 5;15(5):363-75.
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| REF 40 |
Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60.
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| REF 41 |
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209.
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| REF 42 |
Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase. Biochem J. 2013 Mar 15;450(3):629-38.
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| REF 43 |
X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein. Int J Biochem Cell Biol. 2012 Mar;44(3):489-95.
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| REF 44 |
Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association. PLoS One. 2011;6(12):e28511.
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| REF 45 |
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17.
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| REF 46 |
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res. 2009 Oct;19(10):1905-11.
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| REF 47 |
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000 Jul 7;102(1):43-53.
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| REF 48 |
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol. 2004 Sep;6(9):849-60.
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| REF 49 |
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 2000 Dec 21-28;408(6815):1004-8.
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| REF 50 |
Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. J Biol Chem. 2003 Dec 26;278(52):52660-72.
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| REF 51 |
The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):58-66.
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| REF 52 |
Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. Nat Cell Biol. 2001 Feb;3(2):128-33.
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| REF 53 |
Domain organization of XAF1 and the identification and characterization of XIAP(RING) -binding domain of XAF1. Protein Sci. 2012 Oct;21(10):1418-28.
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| REF 54 |
Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. J Biol Chem. 2007 Sep 7;282(36):26202-9.
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| REF 55 |
An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13;279(33):34087-90.
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| REF 56 |
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis. J Cell Sci. 2009 Aug 1;122(Pt 15):2651-61.
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| REF 57 |
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999 Jan 4;18(1):179-87.
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