Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Ras-related C3 botulinum toxin substrate 1 (RAC1) | Literature-reported | Target Info | ||
UniProt ID | RAC1_HUMAN | ||||
Gene Name | RAC1 | ||||
Gene ID | 5879 |
Interacting TTD Target Information | Top | ||||
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Interacting Successful Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Cellular inhibitor of apoptosis 1 (BIRC2) | Target Info | PPI Info | [2] | |
X-linked inhibitor of apoptosis protein (XIAP) | Target Info | PPI Info | [2] | ||
Interacting Literature-reported Target(s) | Ras-related C3 botulinum toxin substrate 1 (RAC1) | Target Info | PPI Info | [3] | |
PAK-1 protein kinase (PAK1) | Target Info | PPI Info | [4] | ||
PAK-2 protein kinase (PAK2) | Target Info | PPI Info | [5] | ||
Beta-chimaerin (CHN2) | Target Info | PPI Info | [6] | ||
T-lymphoma invasion and metastasis 1 (TIAM1) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol Cell Proteomics. 2007 May;6(5):835-44. | ||||
REF 2 | AMPylation of Rho GTPases subverts multiple host signaling processes. J Biol Chem. 2014 Nov 21;289(47):32977-88. | ||||
REF 3 | The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2. Traffic. 2010 Feb;11(2):198-209. | ||||
REF 4 | Integrin 7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. Blood. 2011 Jun 9;117(23):6202-13. | ||||
REF 5 | Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J Biol Chem. 1998 Apr 10;273(15):8776-82. | ||||
REF 6 | Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 2006 May 17;25(10):2062-74. | ||||
REF 7 | Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature. 2000 Dec 7;408(6813):682-8. |
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