Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T97613 Target Info
Target Name Melatonin receptor type 1A (MTNR1A)
Synonyms Mel1a receptor; Mel1AR; Mel-1A-R
Target Type Successful Target
Gene Name MTNR1A
Biochemical Class GPCR rhodopsin
UniProt ID
MTR1A_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Ras-related C3 botulinum toxin substrate 1 (RAC1) Literature-reported Target Interacting Protein Info
UniProt ID
RAC1_HUMAN 
Synonyms TC25; Ras-like protein TC25; p21-Rac1; MIG5; Cell migration-inducing gene5 protein; Cell migration-inducing gene 5 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Protein Name Ras-related protein Rab-10 (RAB10) Interacting Protein Interacting Protein Info
UniProt ID
RAB10_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Protein Name Leucine-rich repeat-containing protein 59 (LRRC59) Interacting Protein Interacting Protein Info
UniProt ID
LRC59_HUMAN 
Synonyms p34
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Target Name Filamin A (FLNA) Clinical trial Target Interacting Protein Info
UniProt ID
FLNA_HUMAN 
Synonyms Non-muscle filamin; Nonmuscle filamin; FLN-A; FLN1; FLN; Filamin-A; Filamin-1; Filamin 1; Endothelial actin-binding protein; Endothelial actin cytoskeleton; Alpha-filamin; Actin-binding protein 280; ABP-280
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [2]
Interacting Protein Name Transmembrane protein 33 (TMEM33) Interacting Protein Interacting Protein Info
UniProt ID
TMM33_HUMAN 
Synonyms 1600019D15Rik; SHINC3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Guanine nucleotide-binding protein subunit beta-4 (GNB4) Interacting Protein Interacting Protein Info
UniProt ID
GBB4_HUMAN 
Synonyms CMTD1F
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Guanine nucleotide-binding [+] 3 Guanine nucleotide-binding +
Interacting Protein Name Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1) Interacting Protein Interacting Protein Info
UniProt ID
GNAI1_HUMAN 
Synonyms Gi
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Reconstituted Complex [2]
Interacting Protein Name Guanine nucleotide-binding protein G(k) subunit alpha (GNAI3) Interacting Protein Interacting Protein Info
UniProt ID
GNAI3_HUMAN 
Synonyms 87U6; ARCND1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [2]
Interacting Protein Name Adenylate cyclase-inhibiting G alpha protein (GNAI2) Interacting Protein Interacting Protein Info
UniProt ID
GNAI2_HUMAN 
Synonyms GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [2]
Isomerases [+] 1 Isomerases +
Interacting Protein Name Protein disulfide-isomerase A6 (PDIA6) Interacting Protein Interacting Protein Info
UniProt ID
PDIA6_HUMAN 
Synonyms ERP5; P5; TXNDC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Other proteins [+] 7 Other proteins +
Interacting Target Name Opioid receptor sigma 2 (PGRMC1) Literature-reported Target Interacting Protein Info
UniProt ID
PGRC1_HUMAN 
Synonyms PGRMC; mPR; Membrane-associated progesterone receptor component 1; Membraneassociated progesterone receptor component 1; IZA; HPR6.6; Dap1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Target Name Calreticulin (CALR) Literature-reported Target Interacting Protein Info
UniProt ID
CALR_HUMAN 
Synonyms HACBP; grp60; ERp60; ERC; Endoplasmic reticulum resident protein 60; CRTC; CRP55; Calregulin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Protein Name Calnexin (CANX) Interacting Protein Interacting Protein Info
UniProt ID
CALX_HUMAN 
Synonyms CNX; IP90; P90
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Protein Name Elongation factor 1-gamma (EEF1G) Interacting Protein Interacting Protein Info
UniProt ID
EF1G_HUMAN 
Synonyms EF1G; GIG35
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Protein Name Insulin receptor substrate 4 (IRS4) Interacting Protein Interacting Protein Info
UniProt ID
IRS4_HUMAN 
Synonyms IRS.4; PY160
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0) Interacting Protein Interacting Protein Info
UniProt ID
ROA0_HUMAN 
Synonyms HNRPA0
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Protein Name VAMP-associated protein B/C (VAPB) Interacting Protein Interacting Protein Info
UniProt ID
VAPB_HUMAN 
Synonyms ALS8; VAMP.B; VAP.B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
References  Top
REF 1 Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol Cell Proteomics. 2007 May;6(5):835-44.
REF 2 Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. J Pineal Res. 2016 Jan;60(1):95-108.
REF 3 Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. Mol Endocrinol. 1999 Dec;13(12):2025-38.

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