| References |
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| REF 1 |
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
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| REF 2 |
Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem. 2000 Sep 1;275(35):27354-9.
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| REF 3 |
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005 Feb 18;307(5712):1098-101.
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| REF 4 |
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7200-5.
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| REF 5 |
Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett. 2003 Feb 11;536(1-3):180-6.
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| REF 6 |
Role of growth arrest and DNA damage-inducible in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury. Am J Respir Crit Care Med. 2011 Nov 1;184(9):1030-40.
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| REF 7 |
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation. Cell Death Differ. 2010 Sep;17(9):1448-62.
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| REF 8 |
Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J Biol Chem. 2005 Sep 9;280(36):31924-35.
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| REF 9 |
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell. 2009 Feb 6;136(3):535-50.
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| REF 10 |
Pectenotoxin-2 represses telomerase activity in human leukemia cells through suppression of hTERT gene expression and Akt-dependent hTERT phosphorylation. FEBS Lett. 2008 Oct 15;582(23-24):3263-9.
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| REF 11 |
The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells. Oncogene. 2005 Aug 18;24(35):5482-91.
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| REF 12 |
Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. J Biol Chem. 2001 Aug 31;276(35):32663-9.
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| REF 13 |
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem. 2001 Feb 2;276(5):3517-23.
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| REF 14 |
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol. 2001 Nov;3(11):973-82.
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| REF 15 |
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem. 2004 Sep 24;279(39):41189-96.
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| REF 16 |
VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. PLoS One. 2013;8(1):e55724.
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| REF 17 |
Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation. 2010 Jan 5;121(1):132-42.
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| REF 18 |
Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. J Biol Chem. 2002 Apr 12;277(15):12874-8.
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| REF 19 |
Phosphorylation and regulation of Raf by Akt (protein kinase B). Science. 1999 Nov 26;286(5445):1741-4.
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| REF 20 |
PTH inactivates the AKT survival pathway in the colonic cell line Caco-2. Biochim Biophys Acta. 2010 Mar;1803(3):343-51.
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| REF 21 |
Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis. 2013 Sep;34(9):2061-70.
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| REF 22 |
Down-regulation of Notch-dependent transcription by Akt in vitro. FEBS Lett. 2008 May 28;582(12):1693-9.
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| REF 23 |
Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. Elife. 2017 Mar 7;6. pii: e19594.
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| REF 24 |
Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 2002 Aug 15;35(4):697-709.
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| REF 25 |
Protein kinase Czeta is a negative regulator of protein kinase B activity. J Biol Chem. 1999 Mar 26;274(13):8589-96.
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| REF 26 |
Activated cdc42-associated kinase is up-regulated in non-small-cell lung cancer and necessary for FGFR-mediated AKT activation. Mol Carcinog. 2016 May;55(5):853-63.
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| REF 27 |
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 1999 Sep 2;401(6748):82-5.
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| REF 28 |
Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem. 2010 Feb 5;285(6):3815-24.
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| REF 29 |
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
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| REF 30 |
Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem. 2005 Sep 9;280(36):31870-81.
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| REF 31 |
USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling. EMBO J. 2017 May 15;36(10):1434-1446.
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| REF 32 |
TNF-alpha induces matrix metalloproteinase-9 expression in A549 cells: role of TNFR1/TRAF2/PKCalpha-dependent signaling pathways. J Cell Physiol. 2010 Aug;224(2):454-64.
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| REF 33 |
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. PLoS One. 2009;4(3):e4686.
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| REF 34 |
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11278-83.
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| REF 35 |
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem. 2002 Oct 18;277(42):39858-66.
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| REF 36 |
COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level. Biochem Biophys Res Commun. 2017 Nov 4;493(1):85-93.
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| REF 37 |
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol. 2006 Nov;26(22):8267-80.
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| REF 38 |
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009 Apr;11(4):397-408.
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| REF 39 |
Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J Biol Chem. 2002 Feb 1;277(5):3743-51.
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