Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T08741 Target Info
Target Name Tyrosine-protein kinase CSK (CSK)
Synonyms Protein-tyrosine kinase CYL; C-Src kinase
Target Type Patented-recorded Target
Gene Name CSK
Biochemical Class Kinase
UniProt ID
CSK_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Caveolin 1 (CAV1) Literature-reported Target Interacting Protein Info
UniProt ID
CAV1_HUMAN 
Synonyms Caveolin-1; Caveolin1; Cav-1; CAV
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [3]
3 Yeast two hybrid [4]
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [6]
3 Protein-Fragment Complementation Assay [5]
4 Yeast two hybrid [7]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Co-fractionation [9]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Transmembrane adapter protein PAG (PAG1) Interacting Protein Interacting Protein Info
UniProt ID
PHAG1_HUMAN 
Synonyms CBP; PAG
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-Western [11]
3 Reconstituted Complex [12]
References  Top
REF 1 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9.
REF 2 Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol. 2001 Jan 8;152(1):181-95.
REF 3 SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. PLoS One. 2014 Mar 14;9(3):e91582.
REF 4 A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase. J Biol Chem. 2002 Mar 15;277(11):8771-4.
REF 5 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 6 Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1:2005.0008.
REF 7 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 8 c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. PLoS One. 2009;4(3):e4686.
REF 9 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 10 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 11 Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling. J Biol Chem. 2003 May 16;278(20):17597-600.
REF 12 Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 2000 May 1;191(9):1591-604.

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