Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T47164 Target Info
Target Name MST-1 protein kinase (STK4)
Synonyms Serine/threonine-protein kinase Krs-2; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4; STE20-like kinase MST1; Mammalian STE20-like protein kinase 1; MST1/N; MST1/C; MST1; MST-1; KRS2
Target Type Literature-reported Target
Gene Name STK4
Biochemical Class Kinase
UniProt ID
STK4_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Striatin (STRN) Interacting Protein Interacting Protein Info
UniProt ID
STRN_HUMAN 
Synonyms SG2NA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Proximity Label-MS [2]
Kinases [+] 3 Kinases +
Interacting Protein Name Serine/threonine-protein kinase 3 (STK3) Interacting Protein Interacting Protein Info
UniProt ID
STK3_HUMAN 
Synonyms KRS1; MST2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
6 Proximity Label-MS [2]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [7]
Interacting Target Name Large tumor suppressor homolog 2 (LATS2) Literature-reported Target Interacting Protein Info
UniProt ID
LATS2_HUMAN 
Synonyms Warts-like kinase; Serine/threonine-protein kinase LATS2; Serine/threonine-protein kinase kpm; KPM; Kinase phosphorylated during mitosis protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Fluorescence Resonance Energy Transfer [8]
Other proteins [+] 7 Other proteins +
Interacting Protein Name Protein salvador homolog 1 (SAV1) Interacting Protein Interacting Protein Info
UniProt ID
SAV1_HUMAN 
Synonyms SAV; WW45; WWP4
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [9]
4 Affinity Capture-MS [3]
5 Affinity Capture-MS [4]
6 Proximity Label-MS [2]
Interacting Protein Name Ras association domain-containing protein 1 (RASSF1) Interacting Protein Interacting Protein Info
UniProt ID
RASF1_HUMAN 
Synonyms 123F2; NORE2A; RASSF1A; RDA32; REH3P21
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Fluorescence Resonance Energy Transfer [8]
5 Proximity Label-MS [2]
Interacting Protein Name Ras association domain-containing protein 2 (RASSF2) Interacting Protein Interacting Protein Info
UniProt ID
RASF2_HUMAN 
Synonyms CENP.34; RASFADIN
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Proximity Label-MS [2]
Interacting Protein Name Ras association domain-containing protein 5 (RASSF5) Interacting Protein Interacting Protein Info
UniProt ID
RASF5_HUMAN 
Synonyms Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Proximity Label-MS [2]
Interacting Protein Name Microtubule-associated protein 1S (MAP1S) Interacting Protein Interacting Protein Info
UniProt ID
MAP1S_HUMAN 
Synonyms BPY2IP1; C19orf5; MAP8; VCY2IP.1; VCY2IP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Proximity Label-MS [2]
Interacting Protein Name Ras association domain-containing protein 3 (RASSF3) Interacting Protein Interacting Protein Info
UniProt ID
RASF3_HUMAN 
Synonyms RASSF5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Proximity Label-MS [2]
Interacting Protein Name Sarcolemmal membrane-associated protein (SLMAP) Interacting Protein Interacting Protein Info
UniProt ID
SLMAP_HUMAN 
Synonyms SLAP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Proximity Label-MS [2]
References  Top
REF 1 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Mol Syst Biol. 2013 Dec 22;9:713.
REF 2 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013 Nov 19;6(302):rs15.
REF 3 Network organization of the human autophagy system. Nature. 2010 Jul 1;466(7302):68-76.
REF 4 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 5 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 6 Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem. 2010 Feb 5;285(6):3815-24.
REF 7 The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007 Oct 31;26(21):4523-34.
REF 8 Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform. J Mol Cell Biol. 2016 Jun;8(3):271-81.
REF 9 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.

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